Literature DB >> 1671710

Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene.

D H Yu1, K Scorsone, M C Hung.   

Abstract

The adenovirus type 5 early region 1A (E1A) gene was introduced into neu-transformed B104-1-1 cells. Cells that expressed E1A possessed reduced transforming activity in vitro and reduced tumorigenicity in nude mice. These results demonstrate that the E1A gene products can act negatively to suppress the transformed phenotype in neu-transformed cells.

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Year:  1991        PMID： 1671710      PMCID： PMC369488          DOI： 10.1128/mcb.11.3.1745-1750.1991

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  33 in total

1.  Neu-protein overexpression in breast cancer. Association with comedo-type ductal carcinoma in situ and limited prognostic value in stage II breast cancer.

Authors:  M J van de Vijver; J L Peterse; W J Mooi; P Wisman; J Lomans; O Dalesio; R Nusse
Journal:  N Engl J Med       Date:  1988-11-10       Impact factor: 91.245

2.  The action of oncogenes in the cytoplasm and nucleus.

Authors:  R A Weinberg
Journal:  Science       Date:  1985-11-15       Impact factor: 47.728

3.  Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.

Authors:  M C Hung; A L Schechter; P Y Chevray; D F Stern; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1986-01       Impact factor: 11.205

4.  Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

Authors:  C I Bargmann; R A Weinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

5.  Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.

Authors:  T Yamamoto; S Ikawa; T Akiyama; K Semba; N Nomura; N Miyajima; T Saito; K Toyoshima
Journal:  Nature       Date:  1986 Jan 16-22       Impact factor: 49.962

6.  Amplification of the proto-neu oncogene facilitates oncogenic activation by a single point mutation.

Authors:  M C Hung; D H Yan; X Y Zhao
Journal:  Proc Natl Acad Sci U S A       Date:  1989-04       Impact factor: 11.205

7.  Amplification and rearrangement of c-erb B proto-oncogenes in cancer of human female genital tract.

Authors:  X Zhang; E Silva; D Gershenson; M C Hung
Journal:  Oncogene       Date:  1989-08       Impact factor: 9.867

8.  Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene.

Authors:  D J Slamon; G M Clark; S G Wong; W J Levin; A Ullrich; W L McGuire
Journal:  Science       Date:  1987-01-09       Impact factor: 47.728

9.  Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene.

Authors:  L Coussens; T L Yang-Feng; Y C Liao; E Chen; A Gray; J McGrath; P H Seeburg; T A Libermann; J Schlessinger; U Francke
Journal:  Science       Date:  1985-12-06       Impact factor: 47.728

10.  The neu gene: an erbB-homologous gene distinct from and unlinked to the gene encoding the EGF receptor.

Authors:  A L Schechter; M C Hung; L Vaidyanathan; R A Weinberg; T L Yang-Feng; U Francke; A Ullrich; L Coussens
Journal:  Science       Date:  1985-09-06       Impact factor: 47.728
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  13 in total

1.  Suppression of E1A-mediated transformation by the p50E4F transcription factor.

Authors:  E R Fernandes; R J Rooney
Journal:  Mol Cell Biol       Date:  1999-07       Impact factor: 4.272

Review 2.  Transcriptional regulation of type I receptor tyrosine kinases in the mammary gland.

Authors:  N P Bates; H C Hurst
Journal:  J Mammary Gland Biol Neoplasia       Date:  1997-04       Impact factor: 2.673

Review 3.  NF-kappaB in pancreatic cancer.

Authors:  Guido M Sclabas; Shuichi Fujioka; Christian Schmidt; Douglas B Evans; Paul J Chiao
Journal:  Int J Gastrointest Cancer       Date:  2003

4.  Negative autoregulation of the neu gene is mediated by a novel enhancer.

Authors:  X Y Zhao; M C Hung
Journal:  Mol Cell Biol       Date:  1992-06       Impact factor: 4.272

5.  Downregulation of microRNA miR-520h by E1A contributes to anticancer activity.

Authors:  Jen-Liang Su; Poshen B Chen; Ya-Huey Chen; Shang-Chih Chen; Yi-Wen Chang; Yi-Hua Jan; Xiaoyun Cheng; Michael Hsiao; Mien-Chie Hung
Journal:  Cancer Res       Date:  2010-05-25       Impact factor: 12.701

6.  Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation.

Authors:  H Yamaguchi; C-T Chen; C-K Chou; A Pal; W Bornmann; G N Hortobagyi; M-C Hung
Journal:  Oncogene       Date:  2010-08-02       Impact factor: 9.867

7.  Expression of the Adenovirus Early Gene 1A Transcription-Repression Domain Alone Downregulates HER2 and Results in the Death of Human Breast Cancer Cells Upregulated for the HER2 Proto-Oncogene.

Authors:  Paul M Loewenstein; Maurice Green
Journal:  Genes Cancer       Date:  2011-07

8.  Axl-gas6 interaction counteracts E1A-mediated cell growth suppression and proapoptotic activity.

Authors:  W P Lee; Y Liao; D Robinson; H J Kung; E T Liu; M C Hung
Journal:  Mol Cell Biol       Date:  1999-12       Impact factor: 4.272

9.  Retention of epidermal growth factor receptors in the endoplasmic reticulum of adenovirus-infected cells.

Authors:  G F Verheijden; W H Moolenaar; H L Ploegh
Journal:  Biochem J       Date:  1992-02-15       Impact factor: 3.857

Review 10.  Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis.

Authors:  G L Nicolson
Journal:  Cancer Metastasis Rev       Date:  1993-09       Impact factor: 9.264
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