PRIMARY OBJECTIVE: To examine the evidence on the metabolic state and nutritional treatment of patients with moderate-to-severe traumatic brain injury (TBI). RESEARCH DESIGN: A systematic review of the literature. METHODS AND PROCEDURES: From 1547 citations, 232 articles were identified and retrieved for text screening. Thirty-six studies fulfilled the criteria and 30 were accepted for data extraction. MAIN OUTCOMES AND RESULTS: Variations in measurement methods and definitions of metabolic abnormalities hampered comparison of studies. However, consistent data demonstrated increased metabolic rate (96-160% of the predicted values), of hypercatabolism (-3 to -16 g N per day) and of upper gastrointestinal intolerance in the majority of the patients during the first 2 weeks after injury. Data also indicated a tendency towards less morbidity and mortality in early fed patients. CONCLUSIONS: The impact of timing, content and ways of administration of nutritional support on neurological outcome after TBI remains to be demonstrated.
PRIMARY OBJECTIVE: To examine the evidence on the metabolic state and nutritional treatment of patients with moderate-to-severe traumatic brain injury (TBI). RESEARCH DESIGN: A systematic review of the literature. METHODS AND PROCEDURES: From 1547 citations, 232 articles were identified and retrieved for text screening. Thirty-six studies fulfilled the criteria and 30 were accepted for data extraction. MAIN OUTCOMES AND RESULTS: Variations in measurement methods and definitions of metabolic abnormalities hampered comparison of studies. However, consistent data demonstrated increased metabolic rate (96-160% of the predicted values), of hypercatabolism (-3 to -16 g N per day) and of upper gastrointestinal intolerance in the majority of the patients during the first 2 weeks after injury. Data also indicated a tendency towards less morbidity and mortality in early fed patients. CONCLUSIONS: The impact of timing, content and ways of administration of nutritional support on neurological outcome after TBI remains to be demonstrated.
Authors: Max Vaickus; Terry Hsieh; Ekaterina Kintsurashvili; Jiyoun Kim; Daniel Kirsch; George Kasotakis; Daniel G Remick Journal: Am J Pathol Date: 2018-11-23 Impact factor: 4.307
Authors: Susan D Horn; Merin Kinikini; Linda W Moore; Flora M Hammond; Murray E Brandstater; Randall J Smout; Ryan S Barrett Journal: Arch Phys Med Rehabil Date: 2015-08 Impact factor: 3.966
Authors: A B Olsen; R A Hetz; H Xue; K R Aroom; D Bhattarai; E Johnson; S Bedi; C S Cox; K Uray Journal: Neurogastroenterol Motil Date: 2013-04-02 Impact factor: 3.598
Authors: Elise L Ma; Allen D Smith; Neemesh Desai; Lumei Cheung; Marie Hanscom; Bogdan A Stoica; David J Loane; Terez Shea-Donohue; Alan I Faden Journal: Brain Behav Immun Date: 2017-07-01 Impact factor: 7.217