Literature DB >> 16716293

Ketamine enhances the expression of serine racemase and D-amino acid oxidase mRNAs in rat brain.

Kazuhide Takeyama1, Masanobu Yoshikawa, Tetsuo Oka, Mitsuru Kawaguchi, Toshiyasu Suzuki, Atsushi Hashimoto.   

Abstract

We have evaluated the effects of the acute administration of noncompetitive N-methyl-D-aspartate receptor antagonist, ketamine, on the expression of serine racemase and D-amino acid oxidase mRNAs in several brain areas of rats. The ketamine administration produced a dose-dependent and transient elevation in the levels of serine racemase and D-amino acid oxidase mRNAs in all the brain areas. These findings suggest that there is a relationship between the gene expression of the d-serine-related enzymes and the blockade of the N-methyl-D-aspartate receptors.

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Year:  2006        PMID： 16716293     DOI： 10.1016/j.ejphar.2006.04.021

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  8 in total

1.  Gabapentin and (S)-pregabalin decrease intracellular D-serine concentrations in PC-12 cells.

Authors:  Nagendra S Singh; Rajib K Paul; Marc C Torjman; Irving W Wainer
Journal:  Neurosci Lett       Date:  2012-12-27       Impact factor: 3.046

Review 2.  Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.

Authors:  Panos Zanos; Ruin Moaddel; Patrick J Morris; Lace M Riggs; Jaclyn N Highland; Polymnia Georgiou; Edna F R Pereira; Edson X Albuquerque; Craig J Thomas; Carlos A Zarate; Todd D Gould
Journal:  Pharmacol Rev       Date:  2018-07       Impact factor: 25.468

3.  Subchronic administration of (R,S)-ketamine induces ketamine ring hydroxylation in Wistar rats.

Authors:  R Moaddel; M Sanghvi; A Ramamoorthy; K Jozwiak; N Singh; C Green; K O'Loughlin; M Torjman; I W Wainer
Journal:  J Pharm Biomed Anal       Date:  2016-03-14       Impact factor: 3.935

4.  Alterations in amino acid levels in mouse brain regions after adjunctive treatment of brexpiprazole with fluoxetine: comparison with (R)-ketamine.

Authors:  Min Ma; Qian Ren; Yuko Fujita; Chun Yang; Chao Dong; Yuta Ohgi; Takashi Futamura; Kenji Hashimoto
Journal:  Psychopharmacology (Berl)       Date:  2017-07-26       Impact factor: 4.530

5.  Behavioral changes and mitochondrial dysfunction in a rat model of schizophrenia induced by ketamine.

Authors:  Larissa de Oliveira; Daiane B Fraga; Renata D De Luca; Leila Canever; Fernando V Ghedim; Maria Paula P Matos; Emilio L Streck; João Quevedo; Alexandra I Zugno
Journal:  Metab Brain Dis       Date:  2011-02-18       Impact factor: 3.584

Review 6.  NMDA receptor regulation by D-serine: new findings and perspectives.

Authors:  Herman Wolosker
Journal:  Mol Neurobiol       Date:  2007-09-12       Impact factor: 5.590

Review 7.  The neurobiology of D-amino acid oxidase and its involvement in schizophrenia.

Authors:  L Verrall; P W J Burnet; J F Betts; P J Harrison
Journal:  Mol Psychiatry       Date:  2009-09-29       Impact factor: 15.992

8.  Alteration in the plasma concentration of a DAAO inhibitor, 3-methylpyrazole-5-carboxylic acid, in the ketamine-treated rats and the influence on the pharmacokinetics of plasma D-tryptophan.

Authors:  Naomi Haruta; Hideaki Iizuka; Kana Ishii; Shunsuke Yoshihara; Hideaki Ichiba; Takeshi Fukushima
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2011       Impact factor: 3.493
  8 in total

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