Literature DB >> 16715676

A case of spontaneous regression of hepatocellular carcinoma with multiple lung metastases.

Hiroyuki Kojima1, Noboru Tanigawa, Shuji Kariya, Atsushi Komemushi, Yuzo Shomura, Satoshi Sawada, Eitatsu Arai, Yoshiro Yokota.   

Abstract

Spontaneous regression of hepatocellular carcinoma (HCC) is a rare phenomenon. We present herein the case of a patient with hepatocellular carcinoma with multiple lung metastases in whom malignancy spontaneously regressed after taking Pheliinus linteus Mycelium. A 79-year-old man consulted our hospital complaining of epigastric discomfort. Abdominal MRI and CT revealed a 3 cm diameter tumor in the liver, and chest CT showed numerous nodular lesions. The levels of alpha-fetoprotein (AFP) and protein induced by vitamin K deficiency or antagonist-II (PIVKA-II) were very high. We diagnosed HCC with multiple lung metastases, and no therapy was performed. Independently he took exact from Phellinus linteus Mycelium for one month, and 6 months later the tumors appeared to be in complete regression. The mechanism underlying this intriguing phenomenon remains unknown.

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Year:  2006        PMID： 16715676     DOI： 10.1007/bf02493281

Source DB:  PubMed          Journal:  Radiat Med        ISSN： 0288-2043


  8 in total

1.  Spontaneous regression of hepatocellular carcinoma associated with elevated levels of interleukin 18.

Authors:  Seigou Abiru; Yuji Kato; Keisuke Hamasaki; Kazuhiko Nakao; Keisuke Nakata; Katsumi Eguchi
Journal:  Am J Gastroenterol       Date:  2002-03       Impact factor: 10.864

2.  Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus.

Authors:  H M Kim; S B Han; G T Oh; Y H Kim; D H Hong; N D Hong; I D Yoo
Journal:  Int J Immunopharmacol       Date:  1996-05

3.  Antitumor action of some Basidiomycetes, especially Phllinus linteus.

Authors:  T Ikekawa; M Nakanishi; N Uehara; G Chihara; F Fukuoka
Journal:  Gan       Date:  1968-04

Review 4.  Spontaneous regression of hepatocellular carcinoma with multiple lung metastases: a case report.

Authors:  M Ikeda; S Okada; H Ueno; T Okusaka; H Kuriyama
Journal:  Jpn J Clin Oncol       Date:  2001-09       Impact factor: 3.019

5.  The inhibitory effect of polysaccharides isolated from Phellinus linteus on tumor growth and metastasis.

Authors:  S B Han; C W Lee; Y J Jeon; N D Hong; I D Yoo; K H Yang; H M Kim
Journal:  Immunopharmacology       Date:  1999-02

6.  Spontaneous regression of recurrent hepatocellular carcinoma after TAE: possible mechanisms of immune mediation.

Authors:  T Nakai; T Shimomura; F Hirokawa
Journal:  Int J Clin Oncol       Date:  2001-06       Impact factor: 3.402

Review 7.  Efforts to explain spontaneous regression of cancer.

Authors:  W H Cole
Journal:  J Surg Oncol       Date:  1981       Impact factor: 3.454

8.  Spontaneous regression of hepatocellular carcinoma: two case reports and a literature review.

Authors:  Hideaki Kato; Makoto Nakamura; Motoe Muramatsu; Etsuto Orito; Ryuzo Ueda; Masashi Mizokami
Journal:  Hepatol Res       Date:  2004-07       Impact factor: 4.288
  8 in total
  9 in total

1.  Spontaneous regression of hepatocellular carcinoma repeated 3 times with invasion of portal vein and inferior vena cava: report on a rare case.

Authors:  Hirokazu Komatsu; Satoshi Imamura; Tomoki Shimizu; Yuya Tsunoda; Tsuyoshi Ito; Jin Imai; Shuichi Nagakubo; Yuichi Morohoshi; Yuriko Fujita
Journal:  Clin J Gastroenterol       Date:  2011-12-09

Review 2.  Historical and current perspectives on therapeutic potential of higher basidiomycetes: an overview.

Authors:  Ruby Varghese; Yogesh Bharat Dalvi; Prasad Y Lamrood; Bharat P Shinde; C K K Nair
Journal:  3 Biotech       Date:  2019-09-17       Impact factor: 2.406

3.  Medicinal mushroom Phellinus linteus as an alternative cancer therapy.

Authors:  Daniel Sliva
Journal:  Exp Ther Med       Date:  2010-05-01       Impact factor: 2.447

4.  Metastatic hepatocellular carcinoma to the pelvis and vertebrae in a patient with chronic hepatitis 'C' with unknown primary.

Authors:  Syed Hussain Abbas; Muhammad Zia Ul Islam Khan; Muhammad Ijaz; Syed Jawad Akhtar Hussain
Journal:  BMJ Case Rep       Date:  2015-02-20

Review 5.  Spontaneous Regression of Hepatocellular Carcinoma with Multiple Lung Metastases: A Case Report and Review of the Literature.

Authors:  Eirini Pectasides; Rebecca Miksad; Sergey Pyatibrat; Amogh Srivastava; Andrea Bullock
Journal:  Dig Dis Sci       Date:  2016-04-01       Impact factor: 3.199

6.  Complete response for advanced liver cancer during sorafenib therapy: case report.

Authors:  Rodolfo Sacco; Irene Bargellini; Giannelli Gianluigi; Marco Bertini; Elena Bozzi; Emanuele Altomare; Valentina Battaglia; Antonio Romano; Michele Bertoni; Alfonso Capria; Giampaolo Bresci; Carlo Bartolozzi
Journal:  BMC Gastroenterol       Date:  2011-01-17       Impact factor: 3.067

7.  Effect of Phellius linteus water extract on benign prostatic hyperplasia.

Authors:  Yu-Na Kim; Min-Sun Kim; Sung-Sik Chun; Jeong-Hwa Choi
Journal:  Nutr Res Pract       Date:  2013-06-03       Impact factor: 1.926

8.  Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis.

Authors:  Hualin Wang; Guang Wu; Hyoung Jin Park; Ping Ping Jiang; Wai-Hung Sit; Leo Jld van Griensven; Jennifer Man-Fan Wan
Journal:  Chin Med       Date:  2012-10-18       Impact factor: 5.455

9.  Spontaneous regression of a large hepatocellular carcinoma with multiple lung metastases.

Authors:  Tamiko Saito; Masafumi Naito; Yuki Matsumura; Hisaaki Kita; Tomoyo Kanno; Yuki Nakada; Mina Hamano; Miho Chiba; Kosaku Maeda; Tomoki Michida; Toshifumi Ito
Journal:  Gut Liver       Date:  2014-08-18       Impact factor: 4.519
  9 in total

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