Literature DB >> 16714603

Isolation of a human monoclonal antibody with strong neutralizing activity against diphtheria toxin.

Mai Kakita1, Tsuyoshi Takahashi, Takako Komiya, Yoshitaka Iba, Takao Tsuji, Yoshikazu Kurosawa, Motohide Takahashi.   

Abstract

We isolated a human monoclonal antibody against diphtheria toxin (DT). It bound to fragment B with a binding activity (Kd) of 3.01 nM. The neutralizing activity assayed by the rabbit skin test was estimated to be 73,600 IU/g. This could be used as a therapeutic drug against DT in place of the traditional equine sera.

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Year:  2006        PMID： 16714603      PMCID： PMC1479265          DOI： 10.1128/IAI.01731-05

Source DB:  PubMed          Journal:  Infect Immun        ISSN： 0019-9567            Impact factor:   3.441


  12 in total

1.  Isolation of human monoclonal antibodies that neutralize human rotavirus.

Authors:  Kyoko Higo-Moriguchi; Yasushi Akahori; Yoshitaka Iba; Yoshikazu Kurosawa; Koki Taniguchi
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

2.  A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures.

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Journal:  Acta Pathol Microbiol Scand Suppl       Date:  1951

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Authors:  A M Pappenheimer
Journal:  Annu Rev Biochem       Date:  1977       Impact factor: 23.643

4.  Localization of the diphtheria toxin receptor-binding domain to the carboxyl-terminal Mr approximately 6000 region of the toxin.

Authors:  J M Rolf; H M Gaudin; L Eidels
Journal:  J Biol Chem       Date:  1990-05-05       Impact factor: 5.157

5.  An immunological study of the diphtheria toxin molecule.

Authors:  A M Pappenheimer; T Uchida; A A Harper
Journal:  Immunochemistry       Date:  1972-09

6.  Diphtheria toxin-dependent adenosine diphosphate ribosylation of aminoacyl transferase II and inhibition of protein synthesis.

Authors:  T Honjo; Y Nishizuka; O Hayaishi
Journal:  J Biol Chem       Date:  1968-06-25       Impact factor: 5.157

7.  Micro cell culture method for determination of diphtheria toxin and antitoxin titres using VERO cells. I. Studies on factors affecting the toxin and antitoxin titration.

Authors:  K Miyamura; S Nishio; A Ito; R Murata; R Kono
Journal:  J Biol Stand       Date:  1974-07

8.  Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor.

Authors:  J G Naglich; J E Metherall; D W Russell; L Eidels
Journal:  Cell       Date:  1992-06-12       Impact factor: 41.582

9.  United States standard diphtheria toxin for the Schick text and the erythema potency assay for the Schick text dose.

Authors:  M F Barile; R W Kolb; M Pittman
Journal:  Infect Immun       Date:  1971-09       Impact factor: 3.441

10.  Heparin-binding EGF-like growth factor, which acts as the diphtheria toxin receptor, forms a complex with membrane protein DRAP27/CD9, which up-regulates functional receptors and diphtheria toxin sensitivity.

Authors:  R Iwamoto; S Higashiyama; T Mitamura; N Taniguchi; M Klagsbrun; E Mekada
Journal:  EMBO J       Date:  1994-05-15       Impact factor: 11.598
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  4 in total

1.  Development of human monoclonal antibodies to diphtheria toxin: A solution for the increasing lack of equine DAT for therapeutic use?

Authors:  Kris Huygen
Journal:  Virulence       Date:  2016-05-19       Impact factor: 5.882

2.  Inhibition of toxic shock by human monoclonal antibodies against staphylococcal enterotoxin B.

Authors:  Eileen A Larkin; Bradley G Stiles; Robert G Ulrich
Journal:  PLoS One       Date:  2010-10-11       Impact factor: 3.240

3.  Identification of a human monoclonal antibody to replace equine diphtheria antitoxin for treatment of diphtheria intoxication.

Authors:  Leila M Sevigny; Brian J Booth; Kirk J Rowley; Brett A Leav; Peter S Cheslock; Kerry A Garrity; Susan E Sloan; William Thomas; Gregory J Babcock; Yang Wang
Journal:  Infect Immun       Date:  2013-08-12       Impact factor: 3.441

4.  Characterization of serum anti-diphtheria antibody activity following administration of equine anti-toxin for suspected diphtheria.

Authors:  Heidi L Smith; Greg Saia; Maria Lobikin; Tejpratap Tiwari; Su-Chun Cheng; Deborah C Molrine
Journal:  Hum Vaccin Immunother       Date:  2017-09-21       Impact factor: 3.452
  4 in total

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