| Literature DB >> 16714108 |
Jesus M Ontoria1, Jose I Martìn Hernando, Savina Malancona, Barbara Attenni, Ian Stansfield, Immacolata Conte, Caterina Ercolani, Jörg Habermann, Simona Ponzi, Marcello Di Filippo, Uwe Koch, Michael Rowley, Frank Narjes.
Abstract
Thieno[3,2-b]pyrroles are a novel class of allosteric inhibitors of HCV NS5B RNA-dependent RNA polymerase which show potent affinity for the NS5B enzyme. Introduction of a polar substituent in the position N1 led to a compound that efficiently blocks subgenomic HCV RNA replication in HUH-7 cells with an EC50 of 2.9 microM.Entities:
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Year: 2006 PMID： 16714108 DOI： 10.1016/j.bmcl.2006.05.012
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823