History of diagnostic enzymology: a review of significant investigations.

This review of the history of diagnostic enzymology includes numerous important publications which were published over 70 years ago by outstanding clinical enzymologists throughout the world. The review includes the clinical enzymology of cardiovascular diseases, skeletal muscle diseases, pulmonary diseases, effusions, neurologic diseases, hematologic diseases, pregnancy, pediatric diseases, cancer, pancreatitis, hepatic diseases, bone diseases and cancer of the prostate. The advent of clinical enzymology thus occurred many years ago.