| Literature DB >> 16713979 |
Rosa Maria Salazar-Gonzalez1, Jan H Niess, David J Zammit, Rajesh Ravindran, Aparna Srinivasan, Joseph R Maxwell, Thomas Stoklasek, Rajwardhan Yadav, Ifor R Williams, Xiubin Gu, Beth A McCormick, Michael A Pazos, Anthony T Vella, Leo Lefrancois, Hans-Christian Reinecker, Stephen J McSorley.
Abstract
T cell activation by dendritic cells (DCs) is critical to the initiation of adaptive immune responses and protection against pathogens. Here, we demonstrate that a specialized DC subset in Peyer's patches (PPs) mediates the rapid activation of pathogen specific T cells. This DC subset is characterized by the expression of the chemokine receptor CCR6 and is found only in PPs. CCR6(+) DCs were recruited into the dome regions of PPs upon invasion of the follicle associated epithelium (FAE) by an enteric pathogen and were responsible for the rapid local activation of pathogen-specific T cells. CCR6-deficient DCs were unable to respond to bacterial invasion of PPs and failed to initiate T cell activation, resulting in reduced defense against oral infection. Thus, CCR6-dependent regulation of DCs is responsible for localized T cell dependent defense against entero-invasive pathogens.Entities:
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Year: 2006 PMID： 16713979 PMCID： PMC2855652 DOI： 10.1016/j.immuni.2006.02.015
Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745