Literature DB >> 16713964

Aging of the immune system: how much can the adaptive immune system adapt?

Nan-Ping Weng1.   

Abstract

The competency of the adaptive immune function decreases with age, primarily because of the decline in production of naive lymphocytes in the bone marrow and thymus as well as the expansion of incompetent memory lymphocytes. Here I discuss the recent progress on age-associated changes in lymphocytes and their effect on the adaptive immune system.

Mesh：

Year:  2006        PMID： 16713964      PMCID： PMC2266981          DOI： 10.1016/j.immuni.2006.05.001

Source DB:  PubMed          Journal:  Immunity        ISSN： 1074-7613            Impact factor:   31.745


  32 in total

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2.  Gene expression characteristics of CD28null memory phenotype CD8+ T cells and its implication in T-cell aging.

Authors:  Monchou Fann; Wai Kan Chiu; William H Wood; Bruce L Levine; Kevin G Becker; Nan-Ping Weng
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Review 3.  Human immunosenescence: is it infectious?

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Review 4.  Insights into thymic aging and regeneration.

Authors:  Dennis D Taub; Dan L Longo
Journal:  Immunol Rev       Date:  2005-06       Impact factor: 12.988

Review 5.  Homeostasis and the age-associated defect of CD4 T cells.

Authors:  Susan Swain; Karen Clise-Dwyer; Laura Haynes
Journal:  Semin Immunol       Date:  2005-10       Impact factor: 11.130

Review 6.  B cell development and receptor diversity during aging.

Authors:  David Allman; Juli P Miller
Journal:  Curr Opin Immunol       Date:  2005-10       Impact factor: 7.486

Review 7.  Humoral immune response and B-cell functions including immunoglobulin class switch are downregulated in aged mice and humans.

Authors:  Daniela Frasca; Richard L Riley; Bonnie B Blomberg
Journal:  Semin Immunol       Date:  2005-10       Impact factor: 11.130

8.  Long-term cytomegalovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbalance in the cytokine production profile in elderly persons.

Authors:  Giovanni Almanzar; Susanne Schwaiger; Brigitte Jenewein; Michael Keller; Dietmar Herndler-Brandstetter; Reinhard Würzner; Diether Schönitzer; Beatrix Grubeck-Loebenstein
Journal:  J Virol       Date:  2005-03       Impact factor: 5.103

9.  Age-related CD8 T cell clonal expansions constrict CD8 T cell repertoire and have the potential to impair immune defense.

Authors:  Ilhem Messaoudi; Joël Lemaoult; Jose A Guevara-Patino; Beatrix M Metzner; Janko Nikolich-Zugich
Journal:  J Exp Med       Date:  2004-11-15       Impact factor: 14.307

10.  Newly generated CD4 T cells in aged animals do not exhibit age-related defects in response to antigen.

Authors:  Laura Haynes; Sheri M Eaton; Eve M Burns; Troy D Randall; Susan L Swain
Journal:  J Exp Med       Date:  2005-03-21       Impact factor: 14.307
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  182 in total

1.  The effects of Spirulina on anemia and immune function in senior citizens.

Authors:  Carlo Selmi; Patrick S C Leung; Laura Fischer; Bruce German; Chen-Yen Yang; Thomas P Kenny; Gerry R Cysewski; M Eric Gershwin
Journal:  Cell Mol Immunol       Date:  2011-01-31       Impact factor: 11.530

Review 2.  Aging and immune function: molecular mechanisms to interventions.

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Journal:  Antioxid Redox Signal       Date:  2011-01-08       Impact factor: 8.401

3.  Potentiation of Th17 cytokines in aging process contributes to the development of colitis.

Authors:  Xinshou Ouyang; Zhuoshun Yang; Ruihua Zhang; Paul Arnaboldi; Geming Lu; Qingshan Li; Weidong Wang; Biao Zhang; Miao Cui; Huafeng Zhang; Jane Liang-Chen; Lihui Qin; Feng Zheng; Bo Huang; Huabao Xiong
Journal:  Cell Immunol       Date:  2010-10-27       Impact factor: 4.868

Review 4.  T cell engineering as therapy for cancer and HIV: our synthetic future.

Authors:  Carl H June; Bruce L Levine
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-10-19       Impact factor: 6.237

5.  Effects of aging on human leukocytes (part II): immunophenotyping of adaptive immune B and T cell subsets.

Authors:  Ulrik Stervbo; Cecilia Bozzetti; Udo Baron; Karsten Jürchott; Sarah Meier; Julia Nora Mälzer; Mikalai Nienen; Sven Olek; Dominika Rachwalik; Axel Ronald Schulz; Avidan Neumann; Nina Babel; Andreas Grützkau; Andreas Thiel
Journal:  Age (Dordr)       Date:  2015-09-02

6.  Dysregulated inflammation as a risk factor for pneumonia in the elderly.

Authors:  Angela R Boyd; Carlos J Orihuela
Journal:  Aging Dis       Date:  2011-12       Impact factor: 6.745

7.  Engineering T cells for cancer: our synthetic future.

Authors:  Robert H Vonderheide; Carl H June
Journal:  Immunol Rev       Date:  2014-01       Impact factor: 12.988

8.  Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling.

Authors:  Won-Woo Lee; Dapeng Cui; Marta Czesnikiewicz-Guzik; Ricardo Z N Vencio; Ilya Shmulevich; Alan Aderem; Cornelia M Weyand; Jörg J Goronzy
Journal:  Rejuvenation Res       Date:  2008-12       Impact factor: 4.663

9.  Aged Mice Exhibit Severe Exacerbations of Dry Eye Disease with an Amplified Memory Th17 Cell Response.

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Journal:  Am J Pathol       Date:  2020-04-11       Impact factor: 4.307

Review 10.  Principles of adoptive T cell cancer therapy.

Authors:  Carl H June
Journal:  J Clin Invest       Date:  2007-05       Impact factor: 14.808
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