| Literature DB >> 16713950 |
Reto Städeli1, Raymond Hoffmans, Konrad Basler.
Abstract
The Wingless/Wnt pathway controls cell fates during animal development and regulates tissue homeostasis as well as stem cell number and differentiation in epithelia. Deregulation of Wnt signaling has been associated with cancer in humans. In the nucleus, the Wingless/Wnt signal is transmitted via the key effector protein Armadillo/beta-catenin. The recent identification and functional analysis of novel Armadillo/beta-catenin interaction partners provide new and exciting insights into the highly complex mechanism of Wingless/Wnt target gene activation.Entities:
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Year: 2006 PMID: 16713950 DOI: 10.1016/j.cub.2006.04.019
Source DB: PubMed Journal: Curr Biol ISSN: 0960-9822 Impact factor: 10.834