Literature DB >> 16713676

Effects of quetiapine on the brain-derived neurotrophic factor expression in the hippocampus and neocortex of rats.

Sung-Woo Park1, Sun-Kyung Lee, Jae-Min Kim, Jin-Sang Yoon, Young-Hoon Kim.   

Abstract

The effects of antipsychotics on the brain-derived neurotrophic factor (BDNF) expression have been controversial. This study aimed to investigate the effects of chronic quetiapine administration on the BDNF mRNA expression in hippocampus and neocortex of rats with or without immobilization stress. The chronic administration (21 days) of quetiapine (10 mg/kg) significantly attenuated the decreased BDNF mRNA expression in the both hippocampal and cortical regions of rats caused by immobilization stress, and significantly increased the BDNF mRNA expression in the dentate gyrus of rats even without the immobilization stress. These results could add some theoretical bases to explain why quetiapine may improve cognitive symptoms of schizophrenia by stimulating BDNF mRNA expression.

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Year:  2006        PMID： 16713676     DOI： 10.1016/j.neulet.2006.03.028

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  15 in total

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Review 4.  BDNF-TrkB signaling and neuroprotection in schizophrenia.

Authors:  Chirayu D Pandya; Ammar Kutiyanawalla; Anilkumar Pillai
Journal:  Asian J Psychiatr       Date:  2012-11-03

5.  Role of quetiapine beyond its clinical efficacy in bipolar disorder: From neuroprotection to the treatment of psychiatric disorders (Review).

Authors:  Márcio G Soeiro-DE-Souza; Vasco Videira Dias; Giovanni Missio; Vicent Balanzá-Martinez; Leandro Valiengo; André F Carvalho; Ricardo Alberto Moreno
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Review 7.  Immediate-Early Genes Modulation by Antipsychotics: Translational Implications for a Putative Gateway to Drug-Induced Long-Term Brain Changes.

Authors:  Andrea de Bartolomeis; Elisabetta F Buonaguro; Gianmarco Latte; Rodolfo Rossi; Federica Marmo; Felice Iasevoli; Carmine Tomasetti
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Review 8.  The association between gene variants and longitudinal structural brain changes in psychosis: a systematic review of longitudinal neuroimaging genetics studies.

Authors:  Julia H Harari; Covadonga M Díaz-Caneja; Joost Janssen; Kenia Martínez; Bárbara Arias; Celso Arango
Journal:  NPJ Schizophr       Date:  2017-11-01

9.  Continuous decrease in serum brain-derived neurotrophic factor (BDNF) levels in a neuropsychiatric syndrome of systemic lupus erythematosus patient with organic brain changes.

Authors:  Atsuko Ikenouchi-Sugita; Reiji Yoshimura; Nobuhisa Ueda; Yuki Kodama; Wakako Umene-Nakano; Jun Nakamura
Journal:  Neuropsychiatr Dis Treat       Date:  2008-12       Impact factor: 2.570

Review 10.  Aripiprazole: from pharmacological profile to clinical use.

Authors:  Guido Di Sciascio; Marco Andrea Riva
Journal:  Neuropsychiatr Dis Treat       Date:  2015-10-13       Impact factor: 2.570
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