Literature DB >> 16713574

VHL and p53: tumor suppressors team up to prevent cancer.

Gregg L Semenza1.   

Abstract

In a recent issue of Molecular Cell, Roe et al. (2006) report that the von Hippel-Lindau (VHL) protein is a positive regulator of p53, thus providing insight into the mechanisms by which VHL loss of function leads to cancer.

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Year:  2006        PMID: 16713574     DOI: 10.1016/j.molcel.2006.05.001

Source DB:  PubMed          Journal:  Mol Cell        ISSN: 1097-2765            Impact factor:   17.970


  7 in total

1.  pVHL-mediated transcriptional repression of c-Myc by recruitment of histone deacetylases.

Authors:  In-Young Hwang; Jae-Seok Roe; Ja-Hwan Seol; Hwa-Ryeon Kim; Eun-Jung Cho; Hong-Duk Youn
Journal:  Mol Cells       Date:  2012-02       Impact factor: 5.034

Review 2.  Molecular principles of metastasis: a hallmark of cancer revisited.

Authors:  Jawad Fares; Mohamad Y Fares; Hussein H Khachfe; Hamza A Salhab; Youssef Fares
Journal:  Signal Transduct Target Ther       Date:  2020-03-12

3.  Hypoxia-inducible factor 1 activation from adipose protein 2-cre mediated knockout of von Hippel-Lindau gene leads to embryonic lethality.

Authors:  Jin Zhang; Yanning Wang; Zhanguo Gao; Zhong Yun; Jianping Ye
Journal:  Clin Exp Pharmacol Physiol       Date:  2012-02       Impact factor: 2.557

Review 4.  Tumor viruses and cancer biology: Modulating signaling pathways for therapeutic intervention.

Authors:  Abhik Saha; Rajeev Kaul; Masanao Murakami; Erle S Robertson
Journal:  Cancer Biol Ther       Date:  2010-11-15       Impact factor: 4.742

5.  VHL missense mutations in the p53 binding domain show different effects on p53 signaling and HIFα degradation in clear cell renal cell carcinoma.

Authors:  Caroline Fanja Razafinjatovo; Daniel Stiehl; Eva Deininger; Markus Rechsteiner; Holger Moch; Peter Schraml
Journal:  Oncotarget       Date:  2017-02-07

6.  Pathogenic missense protein variants affect different functional pathways and proteomic features than healthy population variants.

Authors:  Anna Laddach; Joseph Chi Fung Ng; Franca Fraternali
Journal:  PLoS Biol       Date:  2021-04-28       Impact factor: 8.029

Review 7.  Molecular principles of metastasis: a hallmark of cancer revisited.

Authors:  Jawad Fares; Mohamad Y Fares; Hussein H Khachfe; Hamza A Salhab; Youssef Fares
Journal:  Signal Transduct Target Ther       Date:  2020-03-12
  7 in total

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