| Literature DB >> 16713571 |
Abstract
The mouse embryo is surprisingly resistant to loss of individual cyclins or cyclin-dependent kinases. In a recent issue of Developmental Cell, Berthet et al. (2006) describe collaboration of Cdk2 and Cdk4 in embryogenesis that is revealed only upon their simultaneous loss, resulting in inappropriate activation of the retinoblastoma protein and embryonic lethality.Entities:
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Year: 2006 PMID： 16713571 DOI： 10.1016/j.molcel.2006.05.006
Source DB: PubMed Journal: Mol Cell ISSN： 1097-2765 Impact factor: 17.970