Literature DB >> 16713367

Immunomodulatory role of Withania somnifera root powder on experimental induced inflammation: An in vivo and in vitro study.

M Rasool1, P Varalakshmi.   

Abstract

The aqueous suspension of Withania somnifera root powder was investigated for their in vivo and in vitro immunomodulatory properties. W. somnifera showed potent inhibitory activity towards the complement system, mitogen induced lymphocyte proliferation and delayed-type hypersensitivity reaction. Administration of W. somnifera root powder did not have a significant effect on humoral immune response in rats. Our results report immunosuppressive effect of W. somnifera root powder, thus it could be a candidate for developing as an immunosuppressive drug for the inflammatory diseases.

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Year:  2006        PMID： 16713367     DOI： 10.1016/j.vph.2006.01.015

Source DB:  PubMed          Journal:  Vascul Pharmacol        ISSN： 1537-1891            Impact factor:   5.773


  43 in total

1.  Therapeutic effect of Withania somnifera on pristane-induced model of SLE.

Authors:  Ujla Minhas; Ranjana Minz; Prabir Das; Archana Bhatnagar
Journal:  Inflammopharmacology       Date:  2011-12-13       Impact factor: 4.473

2.  Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells.

Authors:  Joomin Lee; Eun-Ryeong Hahm; Shivendra V Singh
Journal:  Carcinogenesis       Date:  2010-08-19       Impact factor: 4.944

3.  Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo.

Authors:  Silvia D Stan; Eun-Ryeong Hahm; Renaud Warin; Shivendra V Singh
Journal:  Cancer Res       Date:  2008-09-15       Impact factor: 12.701

4.  Withania somnifera as a potential anxiolytic and immunomodulatory agent in acute sleep deprived female Wistar rats.

Authors:  Taranjeet Kaur; Harpal Singh; Rachana Mishra; Shaffi Manchanda; Muskan Gupta; Vedangana Saini; Anuradha Sharma; Gurcharan Kaur
Journal:  Mol Cell Biochem       Date:  2016-12-21       Impact factor: 3.396

5.  DOXIL when combined with Withaferin A (WFA) targets ALDH1 positive cancer stem cells in ovarian cancer.

Authors:  Sham S Kakar; Christopher A Worth; Zhenglong Wang; Kelsey Carter; Mariusz Ratajczak; Pranesh Gunjal
Journal:  J Cancer Stem Cell Res       Date:  2016-04-19

6.  Notch-1 inhibition by Withaferin-A: a therapeutic target against colon carcinogenesis.

Authors:  Srinivas Koduru; Raj Kumar; Sowmyalakshmi Srinivasan; Mark B Evers; Chendil Damodaran
Journal:  Mol Cancer Ther       Date:  2010-01-06       Impact factor: 6.261

Review 7.  Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements.

Authors:  Lily Dara; Jennifer Hewett; Joseph Kartaik Lim
Journal:  World J Gastroenterol       Date:  2008-12-07       Impact factor: 5.742

8.  Withaferin A causes activation of Notch2 and Notch4 in human breast cancer cells.

Authors:  Joomin Lee; Anuradha Sehrawat; Shivendra V Singh
Journal:  Breast Cancer Res Treat       Date:  2012-09-11       Impact factor: 4.872

9.  Appraisal of immunomodulatory potential of Spirulina fusiformis: an in vivo and in vitro study.

Authors:  Mahaboobkhan Rasool; Evan Prince Sabina
Journal:  J Nat Med       Date:  2008-12-18       Impact factor: 2.343

10.  Gastro-protective and Anti-stress Efficacies of Monomethyl Fumarate and a Fumaria indica Extract in Chronically Stressed Rats.

Authors:  Anshul Shakya; Upendra Kumar Soni; Geeta Rai; Shyam Sunder Chatterjee; Vikas Kumar
Journal:  Cell Mol Neurobiol       Date:  2015-07-28       Impact factor: 5.046
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