Literature DB >> 16712861

Application of a column selection system and DryLab software for high-performance liquid chromatography method development.

Ryan M Krisko1, Kieran McLaughlin, Michael J Koenigbauer, Craig E Lunte.   

Abstract

This paper describes a strategy for the development of chromatographic methods for drug candidates based upon the use of simple MS compatible mobile phases and optimization of the chromatographic selectivity through variations of the stationary phase and mobile phase pH. The strategy employs an automated column selection system and a series of HPLC columns, varying in hydrophobicity and silanol activity, in combination with DryLab software to develop chromatographic methods for the separation of mixtures of bupivacaine and its metabolites; acidic, basic, and neutral compounds; and atenolol, nitrendipine, and their degradation products.

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Year:  2006        PMID： 16712861      PMCID： PMC2519830          DOI： 10.1016/j.chroma.2006.04.065

Source DB:  PubMed          Journal:  J Chromatogr A        ISSN： 0021-9673            Impact factor:   4.759


  10 in total

1.  Computer simulation for the convenient optimization of isocratic reversed-phase liquid chromatographic separations by varying temperature and mobile phase strength.

Authors:  R G Wolcott; J W Dolan; L R Snyder
Journal:  J Chromatogr A       Date:  2000-02-11       Impact factor: 4.759

2.  Automatization for development of HPLC methods.

Authors:  M Pfeffer; H Windt
Journal:  Fresenius J Anal Chem       Date:  2001-01-01

3.  High-performance liquid chromatographic method for the quantitation of bupivacaine, 2,6-pipecoloxylidide and 4'-hydroxybupivacaine in plasma and urine.

Authors:  H Kastrissios; M F Hung; E J Triggs
Journal:  J Chromatogr       Date:  1992-05-20

Review 4.  The hydrophobic-subtraction model of reversed-phase column selectivity.

Authors:  L R Snyder; J W Dolan; P W Carr
Journal:  J Chromatogr A       Date:  2004-12-10       Impact factor: 4.759

5.  Computer simulation for the prediction of separation as a function of pH for reversed-phase high-performance liquid chromatography. I. Accuracy of a theory-based model.

Authors:  J A Lewis; D C Lommen; W D Raddatz; J W Dolan; L R Snyder; I Molnar
Journal:  J Chromatogr       Date:  1992-02-21

6.  High-performance liquid chromatographic method for an automated determination of local anaesthetics in human plasma.

Authors:  J Drewe; S Rufer; J Huwyler; E Küsters
Journal:  J Chromatogr B Biomed Sci Appl       Date:  1997-03-28

Review 7.  DryLab computer simulation for high-performance liquid chromatographic method development. II. Gradient elution.

Authors:  J W Dolan; D C Lommen; L R Snyder
Journal:  J Chromatogr       Date:  1989-12-27

8.  Simultaneous determination of bupivacaine and its two metabolites, desbutyl- and 4'-hydroxybupivacaine, in human serum and urine.

Authors:  R L Lindberg; J H Kanto; K K Pihlajamäki
Journal:  J Chromatogr       Date:  1986-12-19

9.  Liquid chromatographic bioanalytical determination of ropivacaine, bupivacaine and major metabolites.

Authors:  T Arvidsson; Y Askemark; M M Halldin
Journal:  Biomed Chromatogr       Date:  1999-06       Impact factor: 1.902

10.  Column liquid chromatographic determination of bupivacaine in human serum using solid-phase extraction.

Authors:  R N Gupta; A Dauphin
Journal:  J Chromatogr B Biomed Appl       Date:  1994-08-05
  10 in total
  4 in total

1.  Novel ultra stable silica-based stationary phases for reversed phase liquid chromatography--study of a hydrophobically assisted weak acid cation exchange phase.

Authors:  Yu Zhang; Peter W Carr
Journal:  J Chromatogr A       Date:  2010-11-16       Impact factor: 4.759

Review 2.  Recent applications of chemometrics in one- and two-dimensional chromatography.

Authors:  Tijmen S Bos; Wouter C Knol; Stef R A Molenaar; Leon E Niezen; Peter J Schoenmakers; Govert W Somsen; Bob W J Pirok
Journal:  J Sep Sci       Date:  2020-03-19       Impact factor: 3.645

3.  Application of Snyder-Dolan classification scheme to the selection of "orthogonal" columns for fast screening of illicit drugs and impurity profiling of pharmaceuticals--I. Isocratic elution.

Authors:  Wenzhe Fan; Yu Zhang; Peter W Carr; Sarah C Rutan; Melanie Dumarey; Adam P Schellinger; Wayne Pritts
Journal:  J Chromatogr A       Date:  2009-08-06       Impact factor: 4.759

4.  Pigeon Pea Husk for Removal of Emerging Contaminants Trimethoprim and Atenolol from Water.

Authors:  Severin Eder; Manuel Torko; Alessia Montalbetti; Paride Azzari; Laura Nyström
Journal:  Molecules       Date:  2021-05-25       Impact factor: 4.411
  4 in total

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