| Literature DB >> 16712780 |
Yasuko Ishikawa1, Gota Cho, Zhenfang Yuan, Noriko Inoue, Yoshiko Nakae.
Abstract
Aquaporin-5 (AQP5), an apical plasma membrane (APM) water channel in salivary glands, lacrimal glands, and airway epithelium, has an important role in fluid secretion. The activation of M3 muscarinic acetylcholine receptors (mAChRs) or alpha1-adrenoceptors on the salivary glands induces salivary fluid secretion. AQP5 localizes in lipid rafts and activation of the M3 mAChRs or alpha1-adrenoceptors induced its translocation together with the lipid rafts to the APM in the interlobular ducts of rat parotid glands. This review focuses on the mechanisms of AQP5 translocation together with lipid rafts to the APM in the interlobular duct cells of parotid glands of normal rats and the impairment of AQP5 translocation in diabetes and senescence.Entities:
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Year: 2006 PMID： 16712780 DOI： 10.1016/j.bbamem.2006.03.026
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002