OBJECTIVE: The clinical manifestations of hyperthyroidism resemble those of the hyperadrenergic state. This study was designed to evaluate the impact of hyperthyroidism on the autonomic nervous system (ANS) and to investigate the relationship between serum thyroid hormone concentrations and parameters of spectral heart rate variability (HRV) analysis in hyperthyroidism. DESIGN AND PATIENTS: Thirty-two hyperthyroid Graves' disease patients (mean age 31 years) and 32 sex-, age-, and body mass index (BMI)-matched normal control subjects were recruited to receive one-channel electrocardiogram (ECG) recording. MEASUREMENTS: The cardiac autonomic nervous function was evaluated by the spectral analysis of HRV, which indicates the autonomic modulation of the sinus node. The correlation coefficients between serum thyroid hormone concentrations and parameters of the spectral HRV analysis were also computed. RESULTS: The hyperthyroid patients revealed significant differences (P < 0.001) compared with the controls in the following HRV parameters: a decrease in total power (TP), very low frequency power (VLF), low frequency power (LF), high frequency power (HF), and HF in normalized units (HF%); and an increase in LF in normalized units (LF%) and in the ratio of LF to HF (LF/HF). After correction of hyperthyroidism in 28 patients, all of the above parameters were restored to levels comparable to those of the controls. In addition, serum thyroid hormone concentrations showed significant correlations with spectral HRV parameters. CONCLUSIONS: Hyperthyroidism is in a sympathovagal imbalanced state, characterized by both increased sympathetic and decreased vagal modulation of the heart rate. These autonomic dysfunctions can be detected simultaneously by spectral analysis of HRV, and the spectral HRV parameters could reflect the disease severity in hyperthyroid patients.
OBJECTIVE: The clinical manifestations of hyperthyroidism resemble those of the hyperadrenergic state. This study was designed to evaluate the impact of hyperthyroidism on the autonomic nervous system (ANS) and to investigate the relationship between serum thyroid hormone concentrations and parameters of spectral heart rate variability (HRV) analysis in hyperthyroidism. DESIGN AND PATIENTS: Thirty-two hyperthyroid Graves' diseasepatients (mean age 31 years) and 32 sex-, age-, and body mass index (BMI)-matched normal control subjects were recruited to receive one-channel electrocardiogram (ECG) recording. MEASUREMENTS: The cardiac autonomic nervous function was evaluated by the spectral analysis of HRV, which indicates the autonomic modulation of the sinus node. The correlation coefficients between serum thyroid hormone concentrations and parameters of the spectral HRV analysis were also computed. RESULTS: The hyperthyroidpatients revealed significant differences (P < 0.001) compared with the controls in the following HRV parameters: a decrease in total power (TP), very low frequency power (VLF), low frequency power (LF), high frequency power (HF), and HF in normalized units (HF%); and an increase in LF in normalized units (LF%) and in the ratio of LF to HF (LF/HF). After correction of hyperthyroidism in 28 patients, all of the above parameters were restored to levels comparable to those of the controls. In addition, serum thyroid hormone concentrations showed significant correlations with spectral HRV parameters. CONCLUSIONS:Hyperthyroidism is in a sympathovagal imbalanced state, characterized by both increased sympathetic and decreased vagal modulation of the heart rate. These autonomic dysfunctions can be detected simultaneously by spectral analysis of HRV, and the spectral HRV parameters could reflect the disease severity in hyperthyroidpatients.
Authors: É J F Peixoto de Miranda; R A Hoshi; M S Bittencourt; A C Goulart; I S Santos; A R Brunoni; M F H S Diniz; A L P Ribeiro; E M Dantas; J G Mill; P A Lotufo; I M Benseñor Journal: Braz J Med Biol Res Date: 2018-08-27 Impact factor: 2.590
Authors: Eliane Ngassam; Marcel Azabji-Kenfack; Aurel T Tankeu; Liliane Mfeukeu-Kuate; Chris-Nadège Nganou-Gnindjio; Camille Mba; Jean Claude Katte; Mesmin Y Dehayem; Jean Claude Mbanya; Eugène Sobngwi Journal: BMC Res Notes Date: 2018-11-15
Authors: Yiyi Zhang; Wendy S Post; Alan Cheng; Elena Blasco-Colmenares; Gordon F Tomaselli; Eliseo Guallar Journal: PLoS One Date: 2013-04-12 Impact factor: 3.240
Authors: Valentin Brusseau; Igor Tauveron; Reza Bagheri; Ukadike Chris Ugbolue; Valentin Magnon; Jean-Baptiste Bouillon-Minois; Valentin Navel; Frédéric Dutheil Journal: Int J Environ Res Public Health Date: 2022-03-18 Impact factor: 3.390