Literature DB >> 1671208

Pleiotropic-resistant phenotype is a multifactorial phenomenon in human colon carcinoma cell lines.

G Toffoli1, A Viel, L Tumiotto, G Biscontin, C Rossi, M Boiocchi.   

Abstract

The biochemical basis of multidrug-resistant (MDR) phenotype has been investigated in drug-resistant sublines independently obtained in our laboratories by single step doxorubicin (DOX) selection of LoVo, DLD1, and SW948 human colon carcinoma (HCC) cell lines. All the chemoresistant sublines have been found to be cross-resistant to DOX, actinomycin-D (ACT-D) and vincristine (VCR) but not to cis-diamminedichloroplatinum (CDDP), and have exhibited an increased expression level of mdr1 mRNA and gp170 glycoprotein. Comparative analyses in drug-resistant and sensitive cells of resistance index, extracellular and intracellular equitoxic DOX concentrations, and mdr1 gene products expression have indicated that MDR phenotype is a multifactorial phenomenon due to different and possibly independent biochemical mechanisms which cooperate, in varying degrees from cell line to cell line, in conferring cellular chemoresistance.

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Year:  1991        PMID： 1671208      PMCID： PMC1971628          DOI： 10.1038/bjc.1991.11

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  24 in total

1.  Functional role for the 170- to 180-kDa glycoprotein specific to drug-resistant tumor cells as revealed by monoclonal antibodies.

Authors:  H Hamada; T Tsuruo
Journal:  Proc Natl Acad Sci U S A       Date:  1986-10       Impact factor: 11.205

2.  Structure and expression of the human MDR (P-glycoprotein) gene family.

Authors:  J E Chin; R Soffir; K E Noonan; K Choi; I B Roninson
Journal:  Mol Cell Biol       Date:  1989-09       Impact factor: 4.272

3.  Combined modalities of resistance in etoposide-resistant human KB cell lines.

Authors:  P J Ferguson; M H Fisher; J Stephenson; D H Li; B S Zhou; Y C Cheng
Journal:  Cancer Res       Date:  1988-11-01       Impact factor: 12.701

4.  Inhibitors of topoisomerase II: structure-activity relationships and mechanism of action of podophyllin congeners.

Authors:  B H Long; D A Stringfellow
Journal:  Adv Enzyme Regul       Date:  1988

5.  Amplification of P-glycoprotein genes in multidrug-resistant mammalian cell lines.

Authors:  J R Riordan; K Deuchars; N Kartner; N Alon; J Trent; V Ling
Journal:  Nature       Date:  1985 Aug 29-Sep 4       Impact factor: 49.962

6.  Structure and expression of a human class pi glutathione S-transferase messenger RNA.

Authors:  T Kano; M Sakai; M Muramatsu
Journal:  Cancer Res       Date:  1987-11-01       Impact factor: 12.701

7.  Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells.

Authors:  C J Chen; J E Chin; K Ueda; D P Clark; I Pastan; M M Gottesman; I B Roninson
Journal:  Cell       Date:  1986-11-07       Impact factor: 41.582

8.  Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance.

Authors:  J H Gerlach; J A Endicott; P F Juranka; G Henderson; F Sarangi; K L Deuchars; V Ling
Journal:  Nature       Date:  1986 Dec 4-10       Impact factor: 49.962

9.  Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein.

Authors:  S P Cole; H F Downes; M L Slovak
Journal:  Br J Cancer       Date:  1989-01       Impact factor: 7.640

10.  Amplification and expression of mdr1 gene in a multidrug resistant variant of small cell lung cancer cell line NCI-H69.

Authors:  J G Reeve; P H Rabbitts; P R Twentyman
Journal:  Br J Cancer       Date:  1989-09       Impact factor: 7.640
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  19 in total

1.  Adriamycin binding assay: a valuable chemosensitivity test in human osteosarcoma.

Authors:  N Baldini; K Scotlandi; M Serra; K Kusuzaki; T Shikita; M C Manara; D Maurici; M Campanacci
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

2.  Synthesis and evaluation of 1,5-disubstituted tetrazoles as rigid analogues of combretastatin A-4 with potent antiproliferative and antitumor activity.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Delia Preti; Mojgan Aghazadeh Tabrizi; Andrea Brancale; Xian-Hua Fu; Jun Li; Su-Zhan Zhang; Ernest Hamel; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2011-12-21       Impact factor: 7.446

3.  Design, synthesis and biological evaluation of arylcinnamide hybrid derivatives as novel anticancer agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Mariem Chayah; M Encarnacion Camacho; Filippo Prencipe; Ernest Hamel; Francesca Consolaro; Giuseppe Basso; Giampietro Viola
Journal:  Eur J Med Chem       Date:  2014-05-10       Impact factor: 6.514

4.  Synthesis, antimitotic and antivascular activity of 1-(3',4',5'-trimethoxybenzoyl)-3-arylamino-5-amino-1,2,4-triazoles.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Filippo Prencipe; Valerio Bertolasi; Michela Cancellieri; Andrea Brancale; Ernest Hamel; Ignazio Castagliuolo; Francesca Consolaro; Elena Porcù; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2014-07-28       Impact factor: 7.446

5.  Convergent synthesis and biological evaluation of 2-amino-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as microtubule targeting agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Andrea Brancale; Antonio Ricci; Ernest Hamel; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2011-06-27       Impact factor: 7.446

6.  Flow cytometric analysis of multidrug-resistance-associated antigen (P-glycoprotein) and DNA ploidy in human colon cancer.

Authors:  M Danova; M Giordano; E Erba; S Palmeri; V Candiloro; A Riccardi; G Ucci; G Mazzini; M D'Incalci; E Ascari
Journal:  J Cancer Res Clin Oncol       Date:  1992       Impact factor: 4.553

7.  Synthesis and biological evaluation of 2-(alkoxycarbonyl)-3-anilinobenzo[b]thiophenes and thieno[2,3-b]pyridines as new potent anticancer agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; Delia Preti; Mojgan Aghazadeh Tabrizi; Marcella Bassetto; Andrea Brancale; Ernest Hamel; Ignazio Castagliuolo; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  J Med Chem       Date:  2013-03-18       Impact factor: 7.446

Review 8.  Human cell lines as models for multidrug resistance in solid tumours.

Authors:  M Clynes; M Heenan; K Hall
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

9.  In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog.

Authors:  Charng Choon Wong; Nagarajan Periasamy; Sreenivasa Rao Sagineedu; Shiran Sidik; Shariful Hasan Sumon; Paul Loadman; Roger Phillips; Nordin Haji Lajis; Johnson Stanslas
Journal:  Invest New Drugs       Date:  2014-05-31       Impact factor: 3.850

10.  Synthesis and biological evaluation of 2-substituted-4-(3',4',5'-trimethoxyphenyl)-5-aryl thiazoles as anticancer agents.

Authors:  Romeo Romagnoli; Pier Giovanni Baraldi; Maria Kimatrai Salvador; M Encarnacion Camacho; Delia Preti; Mojgan Aghazadeh Tabrizi; Marcella Bassetto; Andrea Brancale; Ernest Hamel; Roberta Bortolozzi; Giuseppe Basso; Giampietro Viola
Journal:  Bioorg Med Chem       Date:  2012-10-12       Impact factor: 3.641
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