Literature DB >> 16711001

Changes of expression of stretch-activated potassium channel TREK-1 mRNA and protein in hypertrophic myocardium.

Longxian Cheng1, Fengcheng Su, Nsenga Ripen, Hong Fan, Kai Huang, Min Wang, Hongyu Peng, Chunli Mei, Fang Zhao, Yuhua Liao.   

Abstract

The expression of stretch-activated potassium channel TREK-1 mRNA and protein of hypertrophic myocardium was measured. Using a model of hypertrophy induced by coarctation of abdominal aorta in male Wistar rats, the expression of TREK-1 mRNA and protein was detected by using semi-quantitative RT PCR and Western blot respectively. At 4th and 8th week after constriction of the abdominal aorta, rats developed significant left ventricular hypertrophy. As compared to sham-operated group, stretch-activated potassium channel TREK-1 mRNA was strongly expressed and protein was up-regulated in operation groups (P < 0.05). It was concluded that the expression of TREK-1 was up-regulated in hypertrophic myocardium induced by chronic pressure overload in Wistar rats.

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Year:  2006        PMID： 16711001     DOI： 10.1007/bf02828031

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  9 in total

1.  Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel.

Authors:  F Maingret; A J Patel; F Lesage; M Lazdunski; E Honoré
Journal:  J Biol Chem       Date:  1999-09-17       Impact factor: 5.157

Review 2.  Meeting Koch's postulates for calcium signaling in cardiac hypertrophy.

Authors:  K R Chien
Journal:  J Clin Invest       Date:  2000-05       Impact factor: 14.808

Review 3.  Two ways to feel the pressure: an endothelial Ca(2+) entry channel with dual mechanosensitivity.

Authors:  Klaus Groschner
Journal:  Cardiovasc Res       Date:  2002-01       Impact factor: 10.787

4.  TRAAK is a mammalian neuronal mechano-gated K+ channel.

Authors:  F Maingret; M Fosset; F Lesage; M Lazdunski; E Honoré
Journal:  J Biol Chem       Date:  1999-01-15       Impact factor: 5.157

5.  Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK.

Authors:  F Maingret; A J Patel; F Lesage; M Lazdunski; E Honoré
Journal:  J Biol Chem       Date:  2000-04-07       Impact factor: 5.157

Review 6.  Molecular and functional properties of two-pore-domain potassium channels.

Authors:  F Lesage; M Lazdunski
Journal:  Am J Physiol Renal Physiol       Date:  2000-11

7.  Electrical remodeling in pressure-overload cardiac hypertrophy: role of calcineurin.

Authors:  Z Wang; W Kutschke; K E Richardson; M Karimi; J A Hill
Journal:  Circulation       Date:  2001-10-02       Impact factor: 29.690

Review 8.  The cellular and molecular response of cardiac myocytes to mechanical stress.

Authors:  J Sadoshima; S Izumo
Journal:  Annu Rev Physiol       Date:  1997       Impact factor: 19.318

Review 9.  Hypertrophy of the heart: a new therapeutic target?

Authors:  Norbert Frey; Hugo A Katus; Eric N Olson; Joseph A Hill
Journal:  Circulation       Date:  2004-04-06       Impact factor: 29.690
  9 in total
  3 in total

1.  Effects of acute mechanical stretch on the expression of mechanosensitive potassium channel TREK-1 in rat left ventricle.

Authors:  Fang Zhao; Lijuan Dong; Longxian Cheng; Qiutang Zeng; Fangcheng Su
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2007-08

2.  Expression of stretch-activated two-pore potassium channels in human myometrium in pregnancy and labor.

Authors:  Iain L O Buxton; Cherie A Singer; Jennifer N Tichenor
Journal:  PLoS One       Date:  2010-08-25       Impact factor: 3.240

3.  Systems approach to the study of stretch and arrhythmias in right ventricular failure induced in rats by monocrotaline.

Authors:  David Benoist; Rachel Stones; Alan P Benson; Ewan D Fowler; Mark J Drinkhill; Matthew E L Hardy; David A Saint; Olivier Cazorla; Olivier Bernus; Ed White
Journal:  Prog Biophys Mol Biol       Date:  2014-07-09       Impact factor: 3.667
  3 in total

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