Literature DB >> 16709410

Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11.

Erin L McDearmon1, Ariana C Combs, Kiyotoshi Sekiguchi, Hironobu Fujiwara, James M Ervasti.   

Abstract

alpha-Dystroglycan was quantitatively enriched from mammalian brain based on its uniform reactivity with Vicia villosa agglutinin and resolved into sub-populations possessing or lacking the sulfated glucuronic acid epitope recognized by monoclonal antibody HNK-1. We generated a new monoclonal antibody specific for a glycoepitope on brain alpha-dystroglycan but absent from alpha-dystroglycan expressed in all other tissues examined. Finally, we found that laminin-10/11 preferentially bound to brain alpha-dystroglycan compared to skeletal muscle alpha-dystroglycan. Our results suggest that tissue-specific glycosylation modifies the laminin binding specificity of alpha-dystroglycan.

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Year:  2006        PMID： 16709410     DOI： 10.1016/j.febslet.2006.05.010

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Laminin-β1 impairs spatial learning through inhibition of ERK/MAPK and SGK1 signaling.

Authors:  Ying C Yang; Yun L Ma; Wen T Liu; Eminy H Y Lee
Journal:  Neuropsychopharmacology       Date:  2011-08-17       Impact factor: 7.853

2.  Mutational and functional analysis of Large in a novel CHO glycosylation mutant.

Authors:  Jennifer T Aguilan; Subha Sundaram; Edward Nieves; Pamela Stanley
Journal:  Glycobiology       Date:  2009-05-21       Impact factor: 4.313

3.  HNK-1 sulfotransferase modulates α-dystroglycan glycosylation by 3-O-sulfation of glucuronic acid on matriglycan.

Authors:  M Osman Sheikh; David Venzke; Mary E Anderson; Takako Yoshida-Moriguchi; John N Glushka; Alison V Nairn; Melina Galizzi; Kelley W Moremen; Kevin P Campbell; Lance Wells
Journal:  Glycobiology       Date:  2020-09-28       Impact factor: 4.313

4.  A comparative study of alpha-dystroglycan glycosylation in dystroglycanopathies suggests that the hypoglycosylation of alpha-dystroglycan does not consistently correlate with clinical severity.

Authors:  Cecilia Jimenez-Mallebrera; Silvia Torelli; Lucy Feng; Jihee Kim; Caroline Godfrey; Emma Clement; Rachael Mein; Stephen Abbs; Susan C Brown; Kevin P Campbell; Stephan Kröger; Beril Talim; Haluk Topaloglu; Ros Quinlivan; Helen Roper; Anne M Childs; Maria Kinali; Caroline A Sewry; Francesco Muntoni
Journal:  Brain Pathol       Date:  2008-08-07       Impact factor: 6.508

5.  Large induces functional glycans in an O-mannosylation dependent manner and targets GlcNAc terminals on alpha-dystroglycan.

Authors:  Yihong Hu; Zhi-fang Li; Xiaohua Wu; Qilong Lu
Journal:  PLoS One       Date:  2011-02-09       Impact factor: 3.240

Review 6.  Matriglycan: a novel polysaccharide that links dystroglycan to the basement membrane.

Authors:  Takako Yoshida-Moriguchi; Kevin P Campbell
Journal:  Glycobiology       Date:  2015-04-16       Impact factor: 4.313

7.  The transgenic expression of LARGE exacerbates the muscle phenotype of dystroglycanopathy mice.

Authors:  Charlotte Whitmore; Marta Fernandez-Fuente; Helen Booler; Callum Parr; Manoli Kavishwar; Attia Ashraf; Erica Lacey; Jihee Kim; Rebecca Terry; Mark R Ackroyd; Kim E Wells; Francesco Muntoni; Dominic J Wells; Susan C Brown
Journal:  Hum Mol Genet       Date:  2013-11-13       Impact factor: 6.150

8.  ISPD gene mutations are a common cause of congenital and limb-girdle muscular dystrophies.

Authors:  Sebahattin Cirak; Aileen Reghan Foley; Ralf Herrmann; Tobias Willer; Shu Yau; Elizabeth Stevens; Silvia Torelli; Lina Brodd; Alisa Kamynina; Petr Vondracek; Helen Roper; Cheryl Longman; Rudolf Korinthenberg; Gianni Marrosu; Peter Nürnberg; Daniel E Michele; Vincent Plagnol; Matt Hurles; Steven A Moore; Caroline A Sewry; Kevin P Campbell; Thomas Voit; Francesco Muntoni
Journal:  Brain       Date:  2013-01-03       Impact factor: 13.501

9.  Flow cytometry for the analysis of α-dystroglycan glycosylation in fibroblasts from patients with dystroglycanopathies.

Authors:  Elizabeth Stevens; Silvia Torelli; Lucy Feng; Rahul Phadke; Maggie C Walter; Peter Schneiderat; Ayad Eddaoudi; Caroline A Sewry; Francesco Muntoni
Journal:  PLoS One       Date:  2013-07-22       Impact factor: 3.240

10.  Transgenic Rescue of the LARGEmyd Mouse: A LARGE Therapeutic Window?

Authors:  J C W Hildyard; E Lacey; H Booler; M Hopkinson; D J Wells; S C Brown
Journal:  PLoS One       Date:  2016-07-28       Impact factor: 3.240
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