Literature DB >> 1670897

The oncogenic potential of an activated Hox-2.4 homeobox gene in mouse fibroblasts.

D Aberdam1, V Negreanu, L Sachs, C Blatt.   

Abstract

The homeobox gene Hox-2.4 is transcriptionally activated in cells of the mouse myeloid leukemia WEHI-3B. The constitutive Hox-2.4 expression in WEHI-3B cells is due to insertion of a transposable element belonging to the family of intracisternal A particles. In this study, we demonstrated the oncogenic potential of this activated homeobox gene. NIH 3T3 fibroblast clones bearing the activated Hox-2.4 gene produced fibrosarcomas in nude mice.

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Year:  1991        PMID： 1670897      PMCID： PMC359666          DOI： 10.1128/mcb.11.1.554-557.1991

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  26 in total

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Journal:  Nature       Date:  1978-12-07       Impact factor: 49.962

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Authors:  C Blatt; L Sachs
Journal:  Biochem Biophys Res Commun       Date:  1988-11-15       Impact factor: 3.575

4.  A homeodomain substitution changes the regulatory specificity of the deformed protein in Drosophila embryos.

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Journal:  Cell       Date:  1989-11-03       Impact factor: 41.582

5.  A new technique for the assay of infectivity of human adenovirus 5 DNA.

Authors:  F L Graham; A J van der Eb
Journal:  Virology       Date:  1973-04       Impact factor: 3.616

Review 6.  Cellular oncogenes and multistep carcinogenesis.

Authors:  H Land; L F Parada; R A Weinberg
Journal:  Science       Date:  1983-11-18       Impact factor: 47.728

7.  The cloning of normal "mast" cells in tissue culture.

Authors:  D H Pluznik; L Sachs
Journal:  J Cell Physiol       Date:  1965-12       Impact factor: 6.384

8.  Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.

Authors:  H Aviv; P Leder
Journal:  Proc Natl Acad Sci U S A       Date:  1972-06       Impact factor: 11.205

9.  Chromosome mapping of the genes that control differentiation and malignancy in myeloid leukemic cells.

Authors:  J I Azumi; L Sachs
Journal:  Proc Natl Acad Sci U S A       Date:  1977-01       Impact factor: 11.205

10.  Mutations affecting segment number and polarity in Drosophila.

Authors:  C Nüsslein-Volhard; E Wieschaus
Journal:  Nature       Date:  1980-10-30       Impact factor: 49.962
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  20 in total

1.  HOX11, a homeobox-containing T-cell oncogene on human chromosome 10q24.

Authors:  M A Kennedy; R Gonzalez-Sarmiento; U R Kees; F Lampert; N Dear; T Boehm; T H Rabbitts
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-15       Impact factor: 11.205

2.  Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy.

Authors:  F Chen; M R Capecchi
Journal:  Proc Natl Acad Sci U S A       Date:  1999-01-19       Impact factor: 11.205

Review 3.  Hox genes in the lung.

Authors:  C Kappen
Journal:  Am J Respir Cell Mol Biol       Date:  1996-08       Impact factor: 6.914

4.  Cloning and expression of a new HOXC6 transcript encoding a repressing protein.

Authors:  A Chariot; V Castronovo; P Le; C Gillet; M E Sobel; J Gielen
Journal:  Biochem J       Date:  1996-10-01       Impact factor: 3.857

5.  Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif.

Authors:  M L Phelan; I Rambaldi; M S Featherstone
Journal:  Mol Cell Biol       Date:  1995-08       Impact factor: 4.272

6.  Molecular cloning of a diverged homeobox gene that is rapidly down-regulated during the G0/G1 transition in vascular smooth muscle cells.

Authors:  D H Gorski; D F LePage; C V Patel; N G Copeland; N A Jenkins; K Walsh
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

7.  Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a.

Authors:  T Theil; S McLean-Hunter; M Zörnig; T Möröy
Journal:  Nucleic Acids Res       Date:  1993-12-25       Impact factor: 16.971

8.  Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable.

Authors:  K Monica; D P LeBrun; D A Dedera; R Brown; M L Cleary
Journal:  Mol Cell Biol       Date:  1994-12       Impact factor: 4.272

9.  The retroviral oncogene qin belongs to the transcription factor family that includes the homeotic gene fork head.

Authors:  J Li; P K Vogt
Journal:  Proc Natl Acad Sci U S A       Date:  1993-05-15       Impact factor: 11.205

10.  Distinct patterns of DNA methylation in conventional adenomas involving the right and left colon.

Authors:  Devin C Koestler; Jing Li; John A Baron; Gregory J Tsongalis; Lynn F Butterly; Martha Goodrich; Corina Lesseur; Margaret R Karagas; Carmen J Marsit; Jason H Moore; Angeline S Andrew; Amitabh Srivastava
Journal:  Mod Pathol       Date:  2013-07-19       Impact factor: 7.842
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