| Literature DB >> 16707416 |
Asne R Bauskin1, David A Brown, Tamara Kuffner, Heiko Johnen, X Wei Luo, Mark Hunter, Samuel N Breit.
Abstract
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-beta superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis and management of a wide range of cancers. Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.Entities:
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Year: 2006 PMID： 16707416 DOI： 10.1158/0008-5472.CAN-05-4067
Source DB: PubMed Journal: Cancer Res ISSN： 0008-5472 Impact factor: 12.701