| Literature DB >> 16707190 |
Yuichiro Yamada1, Kazuhito Fukuda, Shimpei Fujimoto, Masaya Hosokawa, Katsushi Tsukiyama, Kazuaki Nagashima, Mitsuo Fukushima, Haruhiko Suzuki, Kentaro Toyoda, Mariko Sassa, Shogo Funakoshi, Nobuya Inagaki, Ataru Taniguchi, T Shun Sato, Shinichi Matsumoto, Koichi Tanaka, Yutaka Seino.
Abstract
Evaluation of a patient's pancreatic beta-cell function is important in both diagnosis and treatment of diabetes. We sought to determine beta-cell function with a single sampling of blood. Examination of fasting blood glucose (F-BG, mM) and C-peptide (F-CPR, nM) levels in seven post-islet-transplanted states of four patients revealed a linear relationship between F-BG and F-CPR. Assuming that normal subjects aged <40 years have 100% pancreatic beta-cell function, we developed the secretory units of islets in transplantation (SUIT) as an index of beta-cell function by the formula: 250 x F-CPR/(F-BG-3.43). The SUIT index was correlated with the stimulated C-peptide levels not only in islet-transplanted patients (R2 = 0.68, P < 0.05) but also in type 2 patients (R2 = 0.34, P < 0.001). Since the SUIT index can be calculated from data obtained at a single fasting blood sampling and predict the pancreatic beta-cell function, the formula may be a useful tool in clinical management of diabetes.Entities:
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Year: 2006 PMID： 16707190 DOI： 10.1016/j.diabres.2006.03.030
Source DB: PubMed Journal: Diabetes Res Clin Pract ISSN： 0168-8227 Impact factor: 5.602