| Literature DB >> 16706545 |
Patrick Aschwanden1, Corey R J Stephenson, Erick M Carreira.
Abstract
[reaction: see text] We report a highly enantioselective, catalytic three-component coupling of aldehydes, alkynes, and 4-piperidone hydrochloride hydrate to afford the corresponding tertiary propargylamines in useful yields. The selective cleavage of the piperidone protecting group using either ammonia/EtOH or a polymer-supported scavenger amine furnishes primary propargylamines.Entities:
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Year: 2006 PMID： 16706545 DOI： 10.1021/ol060876w
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005