Literature DB >> 16706526

Norcystine, a new tool for the study of the structure-activity relationship of peptides.

Manoj P Samant1, Jean E Rivier.   

Abstract

[reaction: see text] Norcysteine (Ncy) is an unnatural amino acid possessing an electronegative sulfur atom directly attached to the alpha-carbon atom. We describe the synthesis of Boc-D,L-Ncy(Mob)-OH, the resolution of its methyl ester, and the introduction of both D- and L-Ncy in GnRH analogues.

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Year:  2006        PMID： 16706526     DOI： 10.1021/ol0606740

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  4 in total

1.  Synthesis of protected norcysteines for SPPS compatible with Fmoc-strategy.

Authors:  Manoj P Samant; Jean E Rivier
Journal:  Tetrahedron Lett       Date:  2007-07-16       Impact factor: 2.415

2.  Structure-activity relationship studies of gonadotropin-releasing hormone antagonists containing S-aryl/alkyl norcysteines and their oxidized derivatives.

Authors:  Manoj P Samant; Richard White; Doley J Hong; Glenn Croston; P Michael Conn; Jo Ann Janovick; Jean Rivier
Journal:  J Med Chem       Date:  2007-04-03       Impact factor: 7.446

3.  Ring size in octreotide amide modulates differently agonist versus antagonist binding affinity and selectivity.

Authors:  Christy Rani R Grace; Judit Erchegyi; Manoj Samant; Renzo Cescato; Veronique Piccand; Roland Riek; Jean Claude Reubi; Jean E Rivier
Journal:  J Med Chem       Date:  2008-04-12       Impact factor: 7.446

4.  Ring size of somatostatin analogues (ODT-8) modulates receptor selectivity and binding affinity.

Authors:  Judit Erchegyi; Christy Rani R Grace; Manoj Samant; Renzo Cescato; Veronique Piccand; Roland Riek; Jean Claude Reubi; Jean E Rivier
Journal:  J Med Chem       Date:  2008-04-12       Impact factor: 7.446
  4 in total

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