BACKGROUND: Hyperlactatemia is an important and common complication of severe malaria. We investigated changes in fluid compartment volumes in patients with severe malaria and control patients with the use of bioimpedence analysis. METHODS: We estimated extracellular water and total body water volumes in a total of 180 children: 56 with severe malaria, 94 with moderate malaria, 24 with respiratory tract infection, and 6 with severe diarrhea. RESULTS: There was a mean (+/-SD) decrease in total body water volume of 17+/-24 mL/kg (or 3% of total body water volume) in patients with severe malaria. This compares with a mean (+/-SD) decrease in total body water volume of 33+/-28 mL/kg (or 6% of total body water volume) in patients with severe diarrhea. There was no increase in extracellular water volume in patients with severe malaria, suggesting no significant intravascular volume depletion in patients with severe malaria. There was no relationship between lactatemia and any changes in fluid compartment volumes. CONCLUSIONS: The changes in fluid volumes that were observed are unlikely to be of physiological significance in the pathophysiology of severe malaria.
BACKGROUND:Hyperlactatemia is an important and common complication of severe malaria. We investigated changes in fluid compartment volumes in patients with severe malaria and control patients with the use of bioimpedence analysis. METHODS: We estimated extracellular water and total body water volumes in a total of 180 children: 56 with severe malaria, 94 with moderate malaria, 24 with respiratory tract infection, and 6 with severe diarrhea. RESULTS: There was a mean (+/-SD) decrease in total body water volume of 17+/-24 mL/kg (or 3% of total body water volume) in patients with severe malaria. This compares with a mean (+/-SD) decrease in total body water volume of 33+/-28 mL/kg (or 6% of total body water volume) in patients with severe diarrhea. There was no increase in extracellular water volume in patients with severe malaria, suggesting no significant intravascular volume depletion in patients with severe malaria. There was no relationship between lactatemia and any changes in fluid compartment volumes. CONCLUSIONS: The changes in fluid volumes that were observed are unlikely to be of physiological significance in the pathophysiology of severe malaria.
Authors: Samuel B Nguah; Torsten Feldt; Steffi Hoffmann; Daniel Pelletier; Daniel Ansong; Justice Sylverken; Parisa Mehrfar; Johanna Herr; Christian Thiel; Stephan Ehrhardt; Gerd D Burchard; Jakob P Cramer Journal: Intensive Care Med Date: 2012-08-14 Impact factor: 17.440
Authors: Christine M Cserti-Gazdewich; Aggrey Dhabangi; Charles Musoke; Isaac Ssewanyana; Henry Ddungu; Deborah Nakiboneka-Ssenabulya; Nicolette Nabukeera-Barungi; Arthur Mpimbaza; Walter H Dzik Journal: Am J Trop Med Hyg Date: 2013-01-28 Impact factor: 2.345
Authors: Kathryn Maitland; Samuel Akech; Samson Gwer; Richard Idro; Greg Fegan; Alice C Eziefula; Michael Levin; Charles R J C Newton Journal: PLoS Clin Trials Date: 2007-02-09