BACKGROUND: Clinical symptoms of mixed-species malaria infections have been variously reported as both less severe and more severe than those of single-species infections. METHODS: Oral temperatures were taken from and blood slides were prepared for 2308 adults who presented at outpatient malaria clinics in Tak Province (Thailand) during May-August 1998, May-July 1999, and May-June 2001 with malaria infections diagnosed by 2 expert research microscopists, each of whom was blinded to the other's reports. RESULTS: In each year, temperatures of patients with mixed Plasmodium vivax-Plasmodium falciparum infections were higher than temperatures of patients with P. vivax or P. falciparum infections. In every mixed-species case, P. falciparum parasitemia was higher than P. vivax parasitemia, but patient temperature was not correlated with the parasitemia of either species or with the total parasitemia. CONCLUSIONS: Among adults who self-report to malaria clinics in western Thailand, patients with mixed P. vivax-P. falciparum infections have higher fevers than patients with single-species infections, a distinction that cannot be attributed to differences in parasitemia. This observation warrants more detailed investigations, spanning wider ranges of ages and transmission environments.
BACKGROUND: Clinical symptoms of mixed-species malaria infections have been variously reported as both less severe and more severe than those of single-species infections. METHODS: Oral temperatures were taken from and blood slides were prepared for 2308 adults who presented at outpatientmalaria clinics in Tak Province (Thailand) during May-August 1998, May-July 1999, and May-June 2001 with malaria infections diagnosed by 2 expert research microscopists, each of whom was blinded to the other's reports. RESULTS: In each year, temperatures of patients with mixed Plasmodium vivax-Plasmodium falciparum infections were higher than temperatures of patients with P. vivax or P. falciparum infections. In every mixed-species case, P. falciparum parasitemia was higher than P. vivaxparasitemia, but patient temperature was not correlated with the parasitemia of either species or with the total parasitemia. CONCLUSIONS: Among adults who self-report to malaria clinics in western Thailand, patients with mixed P. vivax-P. falciparum infections have higher fevers than patients with single-species infections, a distinction that cannot be attributed to differences in parasitemia. This observation warrants more detailed investigations, spanning wider ranges of ages and transmission environments.
Authors: Laura M Erhart; Kritsanai Yingyuen; Niphon Chuanak; Nilawan Buathong; Anintita Laoboonchai; R Scott Miller; Steven R Meshnick; Robert A Gasser; Chansuda Wongsrichanalai Journal: Am J Trop Med Hyg Date: 2004-01 Impact factor: 2.345
Authors: F Ellis Mckenzie; Chansuda Wongsrichanalai; Alan J Magill; J Russ Forney; Barnyen Permpanich; Carmen Lucas; Laura M Erhart; Wendy P O'Meara; David L Smith; Jeeraphat Sirichaisinthop; Robert A Gasser Journal: J Parasitol Date: 2006-12 Impact factor: 1.276
Authors: S Chuangchaiya; K Jangpatarapongsa; P Chootong; J Sirichaisinthop; J Sattabongkot; K Pattanapanyasat; K Chotivanich; M Troye-Blomberg; L Cui; R Udomsangpetch Journal: Clin Exp Immunol Date: 2009-12-17 Impact factor: 4.330
Authors: Antonio C Martins; Felipe M Araújo; Cássio B Braga; Maria G S Guimarães; Rudi Nogueira; Rayanne A Arruda; Lícia N Fernandes; Livia R Correa; Rosely Dos S Malafronte; Oswaldo G Cruz; Cláudia T Codeço; Mônica da Silva-Nunes Journal: PeerJ Date: 2015-10-13 Impact factor: 2.984