Literature DB >> 16704932

Homer proteins: implications for neuropsychiatric disorders.

Karen K Szumlinski1, Peter W Kalivas, Paul F Worley.   

Abstract

Homer proteins regulate signal transduction, synaptogenesis and receptor trafficking, in addition to maintaining and regulating extracellular glutamate levels in limbo-corticostriatal brain regions. Converging preclinical observations indicate a potential role for both immediate early gene Homer isoforms and constitutively expressed Homer isoforms in behavioral pathologies associated with neuropsychiatric disorders, such as addiction and/or alcoholism, depression, anxiety, epilepsy and schizophrenia.

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Year:  2006        PMID： 16704932     DOI： 10.1016/j.conb.2006.05.002

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN： 0959-4388            Impact factor:   6.627


  69 in total

Review 1.  New medications for drug addiction hiding in glutamatergic neuroplasticity.

Authors:  P W Kalivas; N D Volkow
Journal:  Mol Psychiatry       Date:  2011-04-26       Impact factor: 15.992

Review 2.  Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.

Authors:  M Foster Olive
Journal:  Eur J Pharmacol       Date:  2010-04-02       Impact factor: 4.432

3.  Postsynaptic TRPV1 triggers cell type-specific long-term depression in the nucleus accumbens.

Authors:  Brad A Grueter; Gabor Brasnjo; Robert C Malenka
Journal:  Nat Neurosci       Date:  2010-11-14       Impact factor: 24.884

4.  Glutamatergic and GABAergic susceptibility loci for heroin and cocaine addiction in subjects of African and European ancestry.

Authors:  Orna Levran; Einat Peles; Matthew Randesi; Joel Correa da Rosa; Jurg Ott; John Rotrosen; Miriam Adelson; Mary Jeanne Kreek
Journal:  Prog Neuropsychopharmacol Biol Psychiatry       Date:  2015-08-12       Impact factor: 5.067

Review 5.  Glutamatergic postsynaptic density protein dysfunctions in synaptic plasticity and dendritic spines morphology: relevance to schizophrenia and other behavioral disorders pathophysiology, and implications for novel therapeutic approaches.

Authors:  Andrea de Bartolomeis; Gianmarco Latte; Carmine Tomasetti; Felice Iasevoli
Journal:  Mol Neurobiol       Date:  2013-09-03       Impact factor: 5.590

6.  Genetic program of neuronal differentiation and growth induced by specific activation of NMDA receptors.

Authors:  Cristina A Ghiani; Luis Beltran-Parrazal; Daniel M Sforza; Jemily S Malvar; Akop Seksenyan; Ruth Cole; Desmond J Smith; Andrew Charles; Pedro A Ferchmin; Jean de Vellis
Journal:  Neurochem Res       Date:  2006-12-27       Impact factor: 3.996

7.  Group I mGluRs and long-term depression: potential roles in addiction?

Authors:  Brad A Grueter; Zoé A McElligott; Danny G Winder
Journal:  Mol Neurobiol       Date:  2007-07-27       Impact factor: 5.590

Review 8.  Homers regulate drug-induced neuroplasticity: implications for addiction.

Authors:  Karen K Szumlinski; Alexis W Ary; Kevin D Lominac
Journal:  Biochem Pharmacol       Date:  2007-07-27       Impact factor: 5.858

9.  A mass spectrometry-based proteomic analysis of Homer2-interacting proteins in the mouse brain.

Authors:  Scott P Goulding; Karen K Szumlinski; Candice Contet; Michael J MacCoss; Christine C Wu
Journal:  J Proteomics       Date:  2017-07-17       Impact factor: 4.044

10.  Transcriptional corepressor SIN3A regulates hippocampal synaptic plasticity via Homer1/mGluR5 signaling.

Authors:  Morgan Bridi; Hannah Schoch; Cédrick Florian; Shane G Poplawski; Anamika Banerjee; Joshua D Hawk; Giulia S Porcari; Camille Lejards; Chang-Gyu Hahn; Karl-Peter Giese; Robbert Havekes; Nelson Spruston; Ted Abel
Journal:  JCI Insight       Date:  2020-03-12
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