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Literature DB >> 16702627

Anticonvulsant effect of amiloride in pentetrazole-induced status epilepticus in mice.

A Ali¹, K P Pillai, F J Ahmad, Y Dua, D Vohora.

Abstract

Inhibition of sodium hydrogen exchangers (NHE) has been shown to diminish seizure activity in various in vitro and in vivo models of epilepsy. In the present study, we examined the effect of amiloride, a sodium hydrogen exchanger inhibitor, against pentetrazole (PTZ)-induced status epilepticus (SE). The study was conducted in mice and status epilepticus was induced by administering ip 50 mg/kg of phenytoin followed 2 hour later by PTZ, 100 mg/kg sc. Amiloride produced dose-dependent protection against PTZ-induced SE.

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Year: 2006 PMID： 16702627

Source DB: PubMed Journal: Pharmacol Rep ISSN： 1734-1140 Impact factor: 3.024

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Cited

12 in total

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Journal: J Mol Neurosci Date: 2014-03-29 Impact factor: 3.444

2. Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function.

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Review 3. Physiological and pathological functions of acid-sensing ion channels in the central nervous system.

Authors: Xiang-Ping Chu; Zhi-Gang Xiong
Journal: Curr Drug Targets Date: 2012-02 Impact factor: 3.465

4. Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model.

Authors: Jarogniew J Luszczki; Katarzyna M Sawicka; Justyna Kozinska; Monika Dudra-Jastrzebska; Stanislaw J Czuczwar
Journal: J Neural Transm (Vienna) Date: 2008-11-22 Impact factor: 3.575

10. Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons.

Authors: Omar Alijevic; Olivier Bignucolo; Echrak Hichri; Zhong Peng; Jan P Kucera; Stephan Kellenberger
Journal: Front Cell Neurosci Date: 2020-02-28 Impact factor: 5.505

Anticonvulsant effect of amiloride in pentetrazole-induced status epilepticus in mice.

1. Down-regulated expression of acid-sensing ion channel 1a in cortical lesions of patients with focal cortical dysplasia.

2. Inhibition of Acid Sensing Ion Channel 3 Aggravates Seizures by Regulating NMDAR Function.

Review 3. Physiological and pathological functions of acid-sensing ion channels in the central nervous system.

4. Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model.

5. Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological models.

Review 6. Acid-sensing ion channels in pain and disease.

Review 7. The Role of ASIC1a in Epilepsy: A Potential Therapeutic Target.

8. Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Chronic Epileptogenesis.

Review 9. Acid-Sensing Ion Channels as Potential Therapeutic Targets in Neurodegeneration and Neuroinflammation.

10. Slowing of the Time Course of Acidification Decreases the Acid-Sensing Ion Channel 1a Current Amplitude and Modulates Action Potential Firing in Neurons.