Jong-Lyel Roh1, Hyo Seon Kim, Ah-Young Kim. 1. Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Songpa-gu, Seoul, South Korea. rohjl@amc.seoul.kr
Abstract
OBJECTIVE: To evaluate whether xerostomia can affect vocal function in an experimental model. DESIGN: Randomized controlled study. SETTING: Academic center. SUBJECTS:Twenty healthy young men. INTERVENTIONS:Glycopyrrolate was administered to induce acute xerostomia in 10 men, and saline was administered to 10 men who served as controls. MAIN OUTCOME MEASURES: Whole salivary flow rate and dry mouth scale were time-serially measured, and subjective and objective vocal functions were checked before and after treatment. The salivary and vocal functions were compared between groups. RESULTS: Significant salivary hypofunction and symptoms developed within 90 minutes after the administration of glycopyrrolate. Vocal effort and phonation threshold pressure significantly increased (P<.005) and voice range profiles decreased in the xerostomia group (P = .003) but not in the control group. Other voice parameters were comparable between groups (P>.05). High correlations were also found between salivary and vocal parameters. CONCLUSION: Our findings suggest that vocal function can be affected by xerostomia.
RCT Entities:
OBJECTIVE: To evaluate whether xerostomia can affect vocal function in an experimental model. DESIGN: Randomized controlled study. SETTING: Academic center. SUBJECTS: Twenty healthy young men. INTERVENTIONS:Glycopyrrolate was administered to induce acute xerostomia in 10 men, and saline was administered to 10 men who served as controls. MAIN OUTCOME MEASURES: Whole salivary flow rate and dry mouth scale were time-serially measured, and subjective and objective vocal functions were checked before and after treatment. The salivary and vocal functions were compared between groups. RESULTS: Significant salivary hypofunction and symptoms developed within 90 minutes after the administration of glycopyrrolate. Vocal effort and phonation threshold pressure significantly increased (P<.005) and voice range profiles decreased in the xerostomia group (P = .003) but not in the control group. Other voice parameters were comparable between groups (P>.05). High correlations were also found between salivary and vocal parameters. CONCLUSION: Our findings suggest that vocal function can be affected by xerostomia.