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Literature DB >> 16700010

The role of plasma-binding proteins in the cellular uptake of lipophilic vitamins and steroids.

Abstract

Steroid hormones and many other lipophilic compounds are believed to enter cells solely by free diffusion through the plasma membrane. However, recent work using a megalin-deficient mouse model has identified a new endocytic pathway responsible for the delivery of steroids to renal and gonadal tissues. This review describes these new pathways for uptake of 25-hydroxy-vitamin-D3 and the gonadal sex-steroids (17beta-estradiol and testosterone) bound to vitamin D-binding protein and sex hormone-binding globulin respectively. Furthermore examples of other lipophilic molecules that enter cells by receptor-mediated pathways will be presented and the receptors responsible for their uptake described.

Entities: Chemical Gene Species

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Year: 2006 PMID： 16700010 DOI： 10.1055/s-2006-925348

Source DB: PubMed Journal: Horm Metab Res ISSN： 0018-5043 Impact factor: 2.936

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Cited

14 in total

1. Heritability and seasonal variability of vitamin D concentrations in male twins.

Authors: Cristina Karohl; Shaoyong Su; Meena Kumari; Vin Tangpricha; Emir Veledar; Viola Vaccarino; Paolo Raggi
Journal: Am J Clin Nutr Date: 2010-10-13 Impact factor: 7.045

2. Sex hormone-binding globulin (SHBG) as an independent determinant of bone mineral density (BMD) among Chinese middle-aged and elderly men.

Authors: Xiao-Yun Zha; Yu Hu; Xiao-Na Pang; Ji-Heng Zhu; Gui-Lin Chang; Li Li
Journal: Endocrine Date: 2014-01-10 Impact factor: 3.633

3. Maternal obesity and vitamin D sufficiency are associated with cord blood vitamin D insufficiency.

Authors: Jami L Josefson; Joseph Feinglass; Alfred W Rademaker; Boyd E Metzger; Dinah M Zeiss; Heather E Price; Craig B Langman
Journal: J Clin Endocrinol Metab Date: 2012-11-08 Impact factor: 5.958

4. Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1.

Authors: Xiaoming Li; Min Xu; Fei Wang; Alison B Kohan; Michael K Haas; Qing Yang; Danwen Lou; Silvana Obici; W Sean Davidson; Patrick Tso
Journal: J Biol Chem Date: 2013-12-05 Impact factor: 5.157

5. Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults.

Authors: May A Beydoun; Eric L Ding; Hind A Beydoun; Toshiko Tanaka; Luigi Ferrucci; Alan B Zonderman
Journal: Am J Clin Nutr Date: 2011-12-14 Impact factor: 7.045

The role of plasma-binding proteins in the cellular uptake of lipophilic vitamins and steroids.

1. Heritability and seasonal variability of vitamin D concentrations in male twins.

2. Sex hormone-binding globulin (SHBG) as an independent determinant of bone mineral density (BMD) among Chinese middle-aged and elderly men.

3. Maternal obesity and vitamin D sufficiency are associated with cord blood vitamin D insufficiency.

4. Apolipoprotein A-IV reduces hepatic gluconeogenesis through nuclear receptor NR1D1.

5. Vitamin D receptor and megalin gene polymorphisms and their associations with longitudinal cognitive change in US adults.

6. Vitamin D-Binding Protein and Risk of Renal Cell Carcinoma in the Cancer Prevention Study-II Cohort.

7. Vitamin D-binding protein, circulating vitamin D and risk of renal cell carcinoma.

8. Redefining Human Vitamin D Sufficiency: Back to the Basics.

9. Association of megalin genetic polymorphisms with prostate cancer risk and prognosis.

10. Circulating 25-hydroxyvitamin D, vitamin D-binding protein and risk of prostate cancer.