AIM: Peroxisome proliferator-activated receptor gamma (PPARgamma) has emerged as a potential therapeutic target in several types of cancer. In ovarian carcinomas, limited and conflicting data on PPARgamma protein expression have been reported. METHODS: The immunoexpression of PPARgamma and its putative target cyclo-oxygenase 2 (COX2) was investigated in tumour tissues from 80 patients with primary and corresponding recurrent ovarian serous carcinomas after conventional platinum-based chemotherapy. RESULTS: PPARgamma expression was observed in 29% of primary and recurrent carcinomas. In the recurrent tumours, PPARgamma expression inversely correlated with COX2 overexpression in both chemosensitive (p = 0.02) and chemoresistant (p = 0.04) carcinomas. CONCLUSIONS: The data indicate that PPARgamma may represent a potential target for second-line treatment in ovarian cancers.
AIM: Peroxisome proliferator-activated receptor gamma (PPARgamma) has emerged as a potential therapeutic target in several types of cancer. In ovarian carcinomas, limited and conflicting data on PPARgamma protein expression have been reported. METHODS: The immunoexpression of PPARgamma and its putative target cyclo-oxygenase 2 (COX2) was investigated in tumour tissues from 80 patients with primary and corresponding recurrent ovarian serous carcinomas after conventional platinum-based chemotherapy. RESULTS:PPARgamma expression was observed in 29% of primary and recurrent carcinomas. In the recurrent tumours, PPARgamma expression inversely correlated with COX2 overexpression in both chemosensitive (p = 0.02) and chemoresistant (p = 0.04) carcinomas. CONCLUSIONS: The data indicate that PPARgamma may represent a potential target for second-line treatment in ovarian cancers.
Authors: H Sato; S Ishihara; K Kawashima; N Moriyama; H Suetsugu; H Kazumori; T Okuyama; M A Rumi; R Fukuda; N Nagasue; Y Kinoshita Journal: Br J Cancer Date: 2000-11 Impact factor: 7.640
Authors: M A Rumi; H Sato; S Ishihara; K Kawashima; S Hamamoto; H Kazumori; T Okuyama; R Fukuda; N Nagasue; Y Kinoshita Journal: Br J Cancer Date: 2001-06-15 Impact factor: 7.640
Authors: Raoul A Droeser; Robert Mechera; Silvio Däster; Benjamin Weixler; Marko Kraljević; Tarik Delko; Uwe Güth; Sylvia Stadlmann; Luigi Terracciano; Gad Singer Journal: BMC Cancer Date: 2016-08-17 Impact factor: 4.430
Authors: Stefanie Meyer; Thomas Vogt; Michael Landthaler; Anna Berand; Albrecht Reichle; Frauke Bataille; Andreas H Marx; Anne Menz; Arndt Hartmann; Leoni A Kunz-Schughart; Peter J Wild Journal: PPAR Res Date: 2009-07-20 Impact factor: 4.964