| Literature DB >> 16698180 |
Phullara B Shelat1, Aminata P Coulibaly, Qun Wang, Albert Y Sun, Grace Y Sun, Agnes Simonyi.
Abstract
The present study investigated the changes in the expression of regulators of G-protein-coupled signaling proteins RGS2, 7 and 8 in gerbil hippocampus to better understand alterations of G-protein-coupled receptors signaling after cerebral ischemia. In situ hybridization revealed a transient, robust early increase in RGS7 mRNA levels in the dentate gyrus after ischemia. RGS8 mRNA expression started to increase at a later time point in the CA3 region but no changes were found for RGS2. Our results show a subtype-, time-, and subregion-specific regulation in mRNA expression of RGS proteins after cerebral ischemia in gerbil hippocampus.Entities:
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Year: 2006 PMID： 16698180 DOI： 10.1016/j.neulet.2006.04.037
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046