| Literature DB >> 16698022 |
Manabu Tsuda1, Ki-Hyeon Seong, Toshiro Aigaki.
Abstract
Plenty of SH3s (POSH) functions as a scaffold protein for the Jun N-terminal kinase (JNK) signal transduction pathway, which leads to cell death in mammalian cultured cells and Drosophila. Here, we show that POSH forms a complex with Apoptosis-linked gene-2 (ALG-2) and ALG-2-interacting protein (ALIX/AIP1) in a calcium-dependent manner. Overexpression of ALG-2 or ALIX in developing imaginal eye discs resulted in roughened or melanized eyes, respectively. These phenotypes were enhanced by co-overexpression of POSH. We found that overexpression of either gene could induce ectopic JNK activation, suggesting that POSH/ALG-2/ALIX may function together in the regulation of the JNK pathway.Entities:
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Year: 2006 PMID： 16698022 DOI： 10.1016/j.febslet.2006.05.005
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124