Literature DB >> 16697793

Nephron sparing surgery for renal cell carcinoma with normal contralateral kidney: 25 years of experience.

Sascha Pahernik1, Frederik Roos, Christian Hampel, Rolf Gillitzer, Sebastian W Melchior, Joachim W Thüroff.   

Abstract

PURPOSE: We report the long-term results of our consecutive series of 504 patients who underwent NSS for cancer suspicious, solid renal tumors in the presence of a normal opposite kidney at our institution since 1979.
MATERIALS AND METHODS: A total of 715 patients underwent NSS since 1969, including 504 for an elective indication, that is with a normal opposite kidney. Of these patients 381 (75.6%) had RCC, 123 (24.4%) had cancer suspicious benign lesions, including 53 (10.5%) with oncocytoma, 33 (6.5%) with angiomyo(lipo)ma, 23 (4.6%) with a complicated cyst and 13 (2.8%) with other benign lesions. Of the 381 patients with RCC 283 (74.3%) had clear cell, 68 (17.8%) had papillary and 30 (7.9%) had chromophobic RCC. Mean tumor diameter was 3.0 cm (range 0.5 to 11.0). Mean followup was 6.77 years (range 0.2 to 24.1). The oncological outcome was studied, including pathological features associated with tumor progression.
RESULTS: Estimated cancer specific survival rates at 5 and 10 years were 98.5% and 96.7%, respectively. Estimated survival rates free of distant metastasis at 5 and 10 years were 97.5% and 95.1%, respectively. Nine patients with localized RCC experienced local recurrence after NSS. Estimated survival rates free of local recurrence at 5 and 10 years were 98.3% and 95.7%, respectively.
CONCLUSIONS: The long-term results of our series support the concept of organ sparing surgery for RCC in the presence of a normal opposite kidney with excellent long-term survival and a low tumor recurrence rate.

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Year:  2006        PMID: 16697793     DOI: 10.1016/S0022-5347(06)00271-0

Source DB:  PubMed          Journal:  J Urol        ISSN: 0022-5347            Impact factor:   7.450


  20 in total

1.  Renal mass biopsy to guide treatment decisions for small incidental renal tumors: a cost-effectiveness analysis.

Authors:  Pari V Pandharipande; Debra A Gervais; Rebecca I Hartman; Mukesh G Harisinghani; Adam S Feldman; Peter R Mueller; G Scott Gazelle
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Review 2.  [Nephron-sparing surgery].

Authors:  F Becker; S Siemer; J Rotering; H Suttmann; M Stöckle
Journal:  Urologe A       Date:  2008-02       Impact factor: 0.639

Review 3.  Important aspects of organ-preserving surgery for renal tumors: indications, new standards, and oncological outcomes.

Authors:  Frank Becker; Stefan Siemer; Jörn Kamradt; Ulrike Zwergel; Michael Stöckle
Journal:  Dtsch Arztebl Int       Date:  2009-02-20       Impact factor: 5.594

Review 4.  [Minimally invasive vs. open surgical procedures in the treatment of renal cell carcinoma].

Authors:  J W Thüroff; F Roos
Journal:  Urologe A       Date:  2015-02       Impact factor: 0.639

5.  Organ-sparing procedures in GU cancer: part 1-organ-sparing procedures in renal and adrenal tumors: a systematic review.

Authors:  Raouf Seyam; Mahmoud I Khalil; Mohamed H Kamel; Waleed M Altaweel; Rodney Davis; Nabil K Bissada
Journal:  Int Urol Nephrol       Date:  2019-01-08       Impact factor: 2.370

Review 6.  [Renal function in the elderly after radical tumor nephrectomy and partial nephrectomy].

Authors:  S Mehralivand; C Thomas; C Hampel; J W Thüroff; F C Roos
Journal:  Urologe A       Date:  2012-10       Impact factor: 0.639

7.  Positive surgical margins are predictors of local recurrence in conservative kidney surgery for pT1 tumors.

Authors:  Patricio Garcia Marchiñena; Sebastián Tirapegui; Ignacio Tobia Gonzalez; Alberto Jurado; Guillermo Gueglio
Journal:  Int Braz J Urol       Date:  2018 May-Jun       Impact factor: 1.541

8.  An evaluation of the timing of surgical complications following nephrectomy: data from the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP).

Authors:  Akshay Sood; Firas Abdollah; Jesse D Sammon; Victor Kapoor; Craig G Rogers; Wooju Jeong; Dane E Klett; Julian Hanske; Christian P Meyer; James O Peabody; Mani Menon; Quoc-Dien Trinh
Journal:  World J Urol       Date:  2015-04-25       Impact factor: 4.226

9.  Mini-Margin nephron sparing surgery for renal cell carcinoma 4 cm or less.

Authors:  Quanlin Li; Hongwei Guan; Jie Qin; Tao Jiang
Journal:  Adv Urol       Date:  2010-08-30

10.  Open nephron-sparing surgery in renal tumors with normal contralateral kidney: A single centre experience of 8 years.

Authors:  N P Gupta; A Kumar; A K Hemal; P N Dogra; A Seth; R Kumar
Journal:  Indian J Urol       Date:  2007-01
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