| Literature DB >> 16697646 |
Atsushi Naganawa1, Tetsuji Saito, Yuuki Nagao, Hiromu Egashira, Maki Iwahashi, Tohru Kambe, Masatoshi Koketsu, Hiroshi Yamamoto, Michiyoshi Kobayashi, Takayuki Maruyama, Shuichi Ohuchida, Hisao Nakai, Kigen Kondo, Masaaki Toda.
Abstract
A series of 4-([2-[alkyl(phenylsulfonyl)amino]phenoxy]methyl)benzoic acids were identified as functional PGE(2) antagonists with selectivity for the EP1 receptor subtype starting from a chemical lead 1, which was found while screening our in-house compound library. Discovery of the optimized analogs 21-23 is presented here and structure-activity relationships (SAR) are also discussed.Entities:
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Year: 2006 PMID： 16697646 DOI： 10.1016/j.bmc.2006.04.038
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641