| Literature DB >> 16697206 |
Kevin W Gillman1, Mendi A Higgins, Graham S Poindexter, Marc Browning, Wendy J Clarke, Sharon Flowers, James E Grace, John B Hogan, Rachel T McGovern, Lawrence G Iben, Gail K Mattson, Astrid Ortiz, Stefanie Rassnick, John W Russell, Ildiko Antal-Zimanyi.
Abstract
A series of novel 5,5-diphenylimidazolones was synthesized and evaluated for activity against the human neuropeptide Y5 receptor. The 3-pyridyl analog 46 demonstrated an IC(50) of 8.3 nM with a favorable pharmacokinetic profile in rats, but was ineffective in reducing food intake.Entities:
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Year: 2006 PMID： 16697206 DOI： 10.1016/j.bmc.2006.04.042
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641