| Literature DB >> 16697193 |
J Robert Merritt1, Laura L Rokosz, Kingsley H Nelson, Bernd Kaiser, Wei Wang, Tara M Stauffer, Lynne E Ozgur, Adriane Schilling, Ge Li, John J Baldwin, Arthur G Taveras, Michael P Dwyer, Jianping Chao.
Abstract
A novel series of 3,4-diaminocyclobut-3-ene-1,2-diones was prepared and found to show potent inhibitory activity of CXCR2 binding and IL-8-mediated chemotaxis of a CXCR2-expressing cell line. Microsome stability and Caco2 studies were subsequently used to show that compounds of this chemotype are predicted to have good oral bioavailability and are thus suitable for pharmaceutical development.Entities:
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Year: 2006 PMID： 16697193 DOI： 10.1016/j.bmcl.2006.04.082
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823