Literature DB >> 16696322

Immunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasia.

Xiaoyong Hu1, Xiaochun Chen, Hao Ping, Zhaohui Chen, Fuqing Zeng, Gongcheng Lu.   

Abstract

To study the expression and significance of the serine protease Omi/HtrA2 in prostate cancer and benign prostatic hyperplasia. The expression of Omi/HtrA2 was assayed by means of immunohistochemical technique in 41 prostate cancer (Cap), 20 benign prostatic hyperplasia (BPH) and 10 normal prostate (NP) specimens. Omi/HtrA2 expression was positive in 30 (73.17%) prostate cancer specimens, and the positive rate of Omi/HtrA2 was lower in well differentiated than in poorly and moderately differentiated groups (P < 0.05). By contrast, the cells in normal prostate and benign prostatic hyperplasia groups showed no or weak expression of Omi/HtrA2. Prostate cancer cells in vivo may need Omi/HtrA2 expression for apoptosis, and that Omi/HtrA2 expression might be involved in prostate cancer development.

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Year:  2005        PMID： 16696322     DOI： 10.1007/bf02896167

Source DB:  PubMed          Journal:  J Huazhong Univ Sci Technolog Med Sci        ISSN： 1672-0733


  10 in total

1.  Inhibitors of apoptosis proteins in prostate cancer cell lines.

Authors:  Kevin R McEleny; R William G Watson; Ronan N T Coffey; Amanda J O'Neill; John M Fitzpatrick
Journal:  Prostate       Date:  2002-05-01       Impact factor: 4.104

2.  Immunohistochemical analysis of Smac/DIABLO expression in human carcinomas and sarcomas.

Authors:  Nam Jin Yoo; Hong Sug Kim; Su Young Kim; Won Sang Park; Cho Hyun Park; Hae Myung Jeon; Eun Sun Jung; Jung Young Lee; Sug Hyung Lee
Journal:  APMIS       Date:  2003-03       Impact factor: 3.205

3.  Characterization of a novel human serine protease that has extensive homology to bacterial heat shock endoprotease HtrA and is regulated by kidney ischemia.

Authors:  L Faccio; C Fusco; A Chen; S Martinotti; J V Bonventre; A S Zervos
Journal:  J Biol Chem       Date:  2000-01-28       Impact factor: 5.157

4.  Identification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interaction.

Authors:  Ramesh Hegde; Srinivasa M Srinivasula; ZhiJia Zhang; Richard Wassell; Rula Mukattash; Lucia Cilenti; Garrett DuBois; Yuri Lazebnik; Antonis S Zervos; Teresa Fernandes-Alnemri; Emad S Alnemri
Journal:  J Biol Chem       Date:  2001-10-17       Impact factor: 5.157

5.  HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.

Authors:  Anne M Verhagen; John Silke; Paul G Ekert; Miha Pakusch; Hitto Kaufmann; Lisa M Connolly; Catherine L Day; Anjali Tikoo; Richard Burke; Carolyn Wrobel; Robert L Moritz; Richard J Simpson; David L Vaux
Journal:  J Biol Chem       Date:  2001-10-16       Impact factor: 5.157

6.  The serine protease Omi/HtrA2 regulates apoptosis by binding XIAP through a reaper-like motif.

Authors:  L Miguel Martins; Ingram Iaccarino; Tencho Tenev; Stephen Gschmeissner; Nicholas F Totty; Nicholas R Lemoine; John Savopoulos; Carol W Gray; Caretha L Creasy; Colin Dingwall; Julian Downward
Journal:  J Biol Chem       Date:  2001-10-15       Impact factor: 5.157

7.  Immunohistochemical analysis of Omi/HtrA2 expression in stomach cancer.

Authors:  Sug Hyung Lee; Jong Woo Lee; Hong Sug Kim; Su Young Kim; Won Sang Park; Sang Ho Kim; Jung Young Lee; Nam Jin Yoo
Journal:  APMIS       Date:  2003-05       Impact factor: 3.205

8.  Identification and cloning of two isoforms of human high-temperature requirement factor A3 (HtrA3), characterization of its genomic structure and comparison of its tissue distribution with HtrA1 and HtrA2.

Authors:  Gui-Ying Nie; Anne Hampton; Ying Li; Jock K Findlay; Lois A Salamonsen
Journal:  Biochem J       Date:  2003-04-01       Impact factor: 3.857

9.  Flavopiridol down-regulates antiapoptotic proteins and sensitizes human breast cancer cells to epothilone B-induced apoptosis.

Authors:  Sylvie Wittmann; Purva Bali; Sreenivasa Donapaty; Ramadevi Nimmanapalli; Fei Guo; Hirohito Yamaguchi; Mei Huang; Richard Jove; Hong Gang Wang; Kapil Bhalla
Journal:  Cancer Res       Date:  2003-01-01       Impact factor: 12.701

10.  Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.

Authors:  Y Suzuki; K Takahashi-Niki; T Akagi; T Hashikawa; R Takahashi
Journal:  Cell Death Differ       Date:  2004-02       Impact factor: 15.828
  10 in total
  2 in total

1.  Expression patterns and bioinformatic analysis of miR-1260a and miR-1274a in Prostate Cancer Tunisian patients.

Authors:  Rahma Said; Yoelsis Garcia-Mayea; Nesrine Trabelsi; Nouha Setti Boubaker; Cristina Mir; Ahlem Blel; Nidhal Ati; Rosanna Paciucci; Javier Hernández-Losa; Soumaya Rammeh; Amine Derouiche; Mohamed Chebil; Matilde E LLeonart; Slah Ouerhani
Journal:  Mol Biol Rep       Date:  2018-09-24       Impact factor: 2.316

Review 2.  IAP proteins as targets for drug development in oncology.

Authors:  Laurence Dubrez; Jean Berthelet; Valérie Glorian
Journal:  Onco Targets Ther       Date:  2013-09-16       Impact factor: 4.147
  2 in total

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