Literature DB >> 16696070

Postmortem diagnosis of Factor V Leiden from paraffin wax embedded tissue.

J S Webb1, G R Standen, C M Collins, C P Case.   

Abstract

Activated protein C resistance resulting from Factor V Leiden is an important inherited thrombophilia disorder which is found in 3.5% of people in the UK. The genetic defect can be detected using the PCR and the diagnosis can be made postmortem from paraffin wax embedded tissue. The presence of Factor V Leiden should be sought in all cases of unexplained sudden death resulting from venous thromboembolism.

Entities:  

Year:  1996        PMID： 16696070      PMCID： PMC408048          DOI： 10.1136/mp.49.3.m180

Source DB:  PubMed          Journal:  Clin Mol Pathol        ISSN： 1355-2910


  10 in total

1.  Diaphragm disease: pathology of disease of the small intestine induced by non-steroidal anti-inflammatory drugs.

Authors:  J Lang; A B Price; A J Levi; M Burke; J M Gumpel; I Bjarnason
Journal:  J Clin Pathol       Date:  1988-05       Impact factor: 3.411

Review 2.  Inherited thrombophilia: resistance to activated protein C as a pathogenic factor of venous thromboembolism.

Authors:  B Dahlbäck
Journal:  Blood       Date:  1995-02-01       Impact factor: 22.113

3.  High prevalence of a mutation in the factor V gene within the U.K. population: relationship to activated protein C resistance and familial thrombosis.

Authors:  N J Beauchamp; M E Daly; K K Hampton; P C Cooper; F E Preston; I R Peake
Journal:  Br J Haematol       Date:  1994-09       Impact factor: 6.998

4.  Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation.

Authors:  J P Vandenbroucke; T Koster; E Briët; P H Reitsma; R M Bertina; F R Rosendaal
Journal:  Lancet       Date:  1994-11-26       Impact factor: 79.321

5.  Mutation in blood coagulation factor V associated with resistance to activated protein C.

Authors:  R M Bertina; B P Koeleman; T Koster; F R Rosendaal; R J Dirven; H de Ronde; P A van der Velden; P H Reitsma
Journal:  Nature       Date:  1994-05-05       Impact factor: 49.962

6.  Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

Authors:  B Dahlbäck; M Carlsson; P J Svensson
Journal:  Proc Natl Acad Sci U S A       Date:  1993-02-01       Impact factor: 11.205

7.  Factor V Leiden: an additional risk factor for thrombosis in protein S deficient families?

Authors:  B P Koeleman; D van Rumpt; K Hamulyák; P H Reitsma; R M Bertina
Journal:  Thromb Haemost       Date:  1995-08       Impact factor: 5.249

8.  Thrombotic risk during pregnancy and puerperium in women with APC-resistance--effective subcutaneous heparin prophylaxis in a pregnant patient.

Authors:  V De Stefano; S Mastrangelo; K Paciaroni; H Ireland; D A Lane; P Scirpa; B Bizzi; G Leone
Journal:  Thromb Haemost       Date:  1995-08       Impact factor: 5.249

9.  High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance)

Authors:  F R Rosendaal; T Koster; J P Vandenbroucke; P H Reitsma
Journal:  Blood       Date:  1995-03-15       Impact factor: 22.113

10.  Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V.

Authors:  M J Heeb; Y Kojima; J S Greengard; J H Griffin
Journal:  Blood       Date:  1995-06-15       Impact factor: 22.113
  10 in total

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