Literature DB >> 16695924

Variation of proliferative activity in leukemic cell populations of patients with acute leukemia.

E F Saunders1, B C Lampkin, A M Mauer.   

Abstract

In 31 children with acute leukemia, the proliferative activity of the leukemic marrow cell population as measured by mitotic and labeling indexes varied widely from patient to patient and from one disease stage to another. Leukemic marrow had a small but statistically significant diurnal variation of proliferative activity. Changes in labeling indexes were directly related to changes in the proportion of large dividing blasts in the marrow. Generation times of dividing leukemic blast cells in 3 patients were similar at diagnosis and in relapse. Changes in proliferative activity of leukemic marrow can be explained by progressive accumulation of nondividing leukemic cells.

Entities:  

Year:  1967        PMID： 16695924      PMCID： PMC297137          DOI： 10.1172/JCI105628

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  13 in total

1.  PROLIFERATION AND MATURATION DEFECT IN ACUTE LEUKAEMIA CELLS.

Authors:  F GAVOSTO; A PILERI; C BACHI; L PEGORARO
Journal:  Nature       Date:  1964-07-04       Impact factor: 49.962

2.  RE-UTILIZATION OF THYMIDINE DURING DEATH OF A CELL.

Authors:  Y MARUYAMA
Journal:  Nature       Date:  1964-01-04       Impact factor: 49.962

3.  Mitotic cycle of ascites tumor cells.

Authors:  R BASERGA
Journal:  Arch Pathol       Date:  1963-02

4.  Comparative study of the kinetics of cellular proliferation of normal and tumorous tissues with the use of tritiated thymidine. I. Dilution of the label and migration of labeled cells.

Authors:  R BASERGA; W E KISIELESKI
Journal:  J Natl Cancer Inst       Date:  1962-02       Impact factor: 13.506

5.  The acute leukemias. Analysis of 322 cases and review of the literature.

Authors:  D R BOGGS; M M WINTROBE; G E CARTWRIGHT
Journal:  Medicine (Baltimore)       Date:  1962-09       Impact factor: 1.889

6.  The use of tritiated thymidine in the study of DNS synthesis and cell turnover in hemopoietic tissues.

Authors:  E P CRONKITE; V P BOND; T M FLIEDNER; J R RUBINI
Journal:  Lab Invest       Date:  1959 Jan-Feb       Impact factor: 5.662

7.  Comparison of the proliferative capacity of acute leukaemia cells in bone marrow and blood.

Authors:  A M MAUER; V FISHER
Journal:  Nature       Date:  1962-03-17       Impact factor: 49.962

8.  Persistence of mitotic circadian rhythm of a transplantable mammary carcinoma after 35 generations: its bearing on the success of treatment with endoxan.

Authors:  A F Badran; J M Echave Llanos
Journal:  J Natl Cancer Inst       Date:  1965-08       Impact factor: 13.506

9.  Characteristics of cell proliferation in four patients with untreated acute leukemia.

Authors:  A M Mauer; V Fisher
Journal:  Blood       Date:  1966-09       Impact factor: 22.113

10.  Proliferative activity of blast cells in leukemia and myelofibrosis. Morphological differences between proliferating and non-proliferating blast cells.

Authors:  S A Killmann
Journal:  Acta Med Scand       Date:  1965-09
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  16 in total

1.  Cell cycle dependency of a T-cell marker on lymphoblasts.

Authors:  H U Schwenk; U Schneider
Journal:  Blut       Date:  1975-11

Review 2.  [Kinetics and regulation of granulocytopoiesis (author's transl)].

Authors:  P Forrer
Journal:  Klin Wochenschr       Date:  1977-03-15

3.  [Defective synthesis of ribosomal nucleic acids in human leukemic cells (author's transl)].

Authors:  S Seeber
Journal:  Z Krebsforsch Klin Onkol Cancer Res Clin Oncol       Date:  1974

4.  [Autoradiographic and enzyme-chemical studies of DNA synthesis in leukemia cells. I. Correlation of thymidine-kinase and 3 H-thymidine labelling index].

Authors:  J Hartje; W Wilmanns
Journal:  Klin Wochenschr       Date:  1970-07-01

5.  Duration of remissions in lymphoblastic leukaemia of childhood.

Authors:  H C Laurie
Journal:  Br Med J       Date:  1968-04-13

6.  Proliferation kinetics of malignant non-Hodgkin's lymphomas related to histopathology of lymph node biopsies.

Authors:  W Lang; S Kienzle; V Diehl
Journal:  Virchows Arch A Pathol Anat Histol       Date:  1980

7.  Dual parameter flow cytometry studies in human lymphomas.

Authors:  S E Shackney; K S Skramstad; R E Cunningham; D J Dugas; T L Lincoln; R J Lukes
Journal:  J Clin Invest       Date:  1980-12       Impact factor: 14.808

8.  Bone marrow cells in the DNA-synthesis-phase in the myelodysplastic syndrome and lymphome.

Authors:  A M Wenthzel; A Porwit; K Lindahl; S Widell; P Reizenstein
Journal:  Med Oncol Tumor Pharmacother       Date:  1992

9.  [Cell kinetics in lymph nodes. I. Determination of deoxyribonucleic acid synthesis time in patients with chronic lymphatic leukemia by means of double labeling with 3H-thymidine and 14C-thymidine in vivo].

Authors:  A D Tsirimbas; K Wittmann; P Dörmer
Journal:  Klin Wochenschr       Date:  1970-08-01

10.  Synchronization and recruitment in acute leukemia.

Authors:  B C Lampkin; T Nagao; A M Mauer
Journal:  J Clin Invest       Date:  1971-10       Impact factor: 14.808
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