Literature DB >> 16691491

The intracellular antigen transport machinery TAP in adaptive immunity and virus escape mechanisms.

Christian Schölz1, Robert Tampé.   

Abstract

The transporter associated with antigen processing (TAP) is a crucial element of the adaptive immune system, which translocates proteasomal degradation products into the endoplasmic reticulum, for transfer of these peptides on major histocompatibility complex (MHC) I molecules within a macromolecular peptide-loading complex. After loading and intracellular transport to the cell surface, these peptide/MHC complexes are monitored by cytotoxic T-lymphocytes. This review summarizes the structural organization and function of the ABC transporter TAP. Furthermore, we discuss human diseases and viral evasion strategies associated with TAP function.

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Year:  2005        PMID： 16691491     DOI： 10.1007/s10863-005-9500-1

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   3.853


  74 in total

Review 1.  TAP deficiency syndrome.

Authors:  S D Gadola; H T Moins-Teisserenc; J Trowsdale; W L Gross; V Cerundolo
Journal:  Clin Exp Immunol       Date:  2000-08       Impact factor: 4.330

Review 2.  Making sense of mass destruction: quantitating MHC class I antigen presentation.

Authors:  Jonathan W Yewdell; Eric Reits; Jacques Neefjes
Journal:  Nat Rev Immunol       Date:  2003-12       Impact factor: 53.106

Review 3.  How do ABC transporters drive transport?

Authors:  Chris van der Does; Robert Tampé
Journal:  Biol Chem       Date:  2004-10       Impact factor: 3.915

4.  The human cytomegalovirus gene product US6 inhibits ATP binding by TAP.

Authors:  E W Hewitt; S S Gupta; P J Lehner
Journal:  EMBO J       Date:  2001-02-01       Impact factor: 11.598

5.  Thermodynamics of peptide binding to the transporter associated with antigen processing (TAP).

Authors:  Lars Neumann; Rupert Abele; Robert Tampé
Journal:  J Mol Biol       Date:  2002-12-13       Impact factor: 5.469

6.  Multiple regions of the transporter associated with antigen processing (TAP) contribute to its peptide binding site.

Authors:  M Nijenhuis; G J Hämmerling
Journal:  J Immunol       Date:  1996-12-15       Impact factor: 5.422

7.  P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site.

Authors:  I L Urbatsch; B Sankaran; J Weber; A E Senior
Journal:  J Biol Chem       Date:  1995-08-18       Impact factor: 5.157

Review 8.  Tapasin-the keystone of the loading complex optimizing peptide binding by MHC class I molecules in the endoplasmic reticulum.

Authors:  F Momburg; P Tan
Journal:  Mol Immunol       Date:  2002-10       Impact factor: 4.407

Review 9.  Structure and mechanism of ABC transporters.

Authors:  Lutz Schmitt; Robert Tampé
Journal:  Curr Opin Struct Biol       Date:  2002-12       Impact factor: 6.809

10.  Asymptomatic deficiency in the peptide transporter associated to antigen processing (TAP).

Authors:  H de la Salle; X Saulquin; I Mansour; S Klayme; D Fricker; J Zimmer; J-P Cazenave; D Hanau; M Bonneville; E Houssaint; G Lefranc; R Naman
Journal:  Clin Exp Immunol       Date:  2002-06       Impact factor: 4.330
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  11 in total

Review 1.  Major histocompatibility complex class I binding predictions as a tool in epitope discovery.

Authors:  Claus Lundegaard; Ole Lund; Søren Buus; Morten Nielsen
Journal:  Immunology       Date:  2010-05-26       Impact factor: 7.397

2.  Downregulation of antigen presentation-associated pathway proteins is linked to poor outcome in triple-negative breast cancer patient tumors.

Authors:  Martin H Pedersen; Brian L Hood; Hans Christian Beck; Thomas P Conrads; Henrik J Ditzel; Rikke Leth-Larsen
Journal:  Oncoimmunology       Date:  2017-03-16       Impact factor: 8.110

3.  Exosome-driven antigen transfer for MHC class II presentation facilitated by the receptor binding activity of influenza hemagglutinin.

Authors:  James S Testa; Geraud S Apcher; Joseph D Comber; Laurence C Eisenlohr
Journal:  J Immunol       Date:  2010-11-03       Impact factor: 5.422

Review 4.  Viral proteins interfering with antigen presentation target the major histocompatibility complex class I peptide-loading complex.

Authors:  Gustav Røder; Linda Geironson; Iain Bressendorff; Kajsa Paulsson
Journal:  J Virol       Date:  2008-04-30       Impact factor: 5.103

Review 5.  MHC class I assembly: out and about.

Authors:  Malini Raghavan; Natasha Del Cid; Syed Monem Rizvi; Larry Robert Peters
Journal:  Trends Immunol       Date:  2008-09       Impact factor: 16.687

6.  Hematopoietic stem cells exhibit a specific ABC transporter gene expression profile clearly distinct from other stem cells.

Authors:  Leilei Tang; Saskia M Bergevoet; Christian Gilissen; Theo de Witte; Joop H Jansen; Bert A van der Reijden; Reinier A P Raymakers
Journal:  BMC Pharmacol       Date:  2010-09-13

7.  Immune regulation and evasion of Mammalian host cell immunity during viral infection.

Authors:  B M Pratheek; Soham Saha; Prasanta K Maiti; Soma Chattopadhyay; Subhasis Chattopadhyay
Journal:  Indian J Virol       Date:  2013-03-15

8.  Purification and reconstitution of the antigen transport complex TAP: a prerequisite for determination of peptide stoichiometry and ATP hydrolysis.

Authors:  Meike Herget; Nina Kreissig; Christian Kolbe; Christian Schölz; Robert Tampé; Rupert Abele
Journal:  J Biol Chem       Date:  2009-10-06       Impact factor: 5.157

9.  Innate immunity and hepatitis C virus infection: a microarray's view.

Authors:  Luigi Buonaguro; Annacarmen Petrizzo; Maria Lina Tornesello; Franco M Buonaguro
Journal:  Infect Agent Cancer       Date:  2012-03-26       Impact factor: 2.965

Review 10.  The Role of Molecular Flexibility in Antigen Presentation and T Cell Receptor-Mediated Signaling.

Authors:  Kannan Natarajan; Jiansheng Jiang; Nathan A May; Michael G Mage; Lisa F Boyd; Andrew C McShan; Nikolaos G Sgourakis; Ad Bax; David H Margulies
Journal:  Front Immunol       Date:  2018-07-17       Impact factor: 7.561
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