Literature DB >> 16691466

Studies of Ca2+ ATPase (SERCA) inhibition.

Giuseppe Inesi1, Suming Hua, Cheng Xu, Hailun Ma, Malini Seth, Anand M Prasad, Carlota Sumbilla.   

Abstract

The Ca(2+) transport ATPase of intracellular membranes (SERCA) can be inhibited by a series of chemical compounds such as Thapsigargin (TG), 2,5-di(tert-butyl)hydroquinone (DBHQ) and 1,3-dibromo-2,4,6-tris (methyl-isothio-uronium) benzene (Br(2)-TITU). These compounds have specific binding sites in the ATPase protein, and different mechanisms of inhibition. On the other hand, SERCA gene silencing offers a convenient and specific method for suppression of SERCA activity in cells. The physiological and pharmacological implications of SERCA inhibition are discussed.

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Year:  2005        PMID： 16691466     DOI： 10.1007/s10863-005-9472-1

Source DB:  PubMed          Journal:  J Bioenerg Biomembr        ISSN： 0145-479X            Impact factor:   3.853


  26 in total

1.  Structural changes in the calcium pump accompanying the dissociation of calcium.

Authors:  Chikashi Toyoshima; Hiromi Nomura
Journal:  Nature       Date:  2002-08-08       Impact factor: 49.962

2.  Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence.

Authors:  D H MacLennan; C J Brandl; B Korczak; N M Green
Journal:  Nature       Date:  1985 Aug 22-28       Impact factor: 49.962

3.  Synthesis of a radioactive azido derivative of thapsigargin and photolabeling of the sarcoplasmic reticulum ATPase.

Authors:  S Hua; G Inesi
Journal:  Biochemistry       Date:  1997-09-30       Impact factor: 3.162

4.  Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L.

Authors:  U Rasmussen; S Brøogger Christensen; F Sandberg
Journal:  Acta Pharm Suec       Date:  1978

5.  Effects of various amino acid 256 mutations on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase function and their role in the cellular adaptive response to thapsigargin.

Authors:  M Yu; J Lin; M Khadeer; Y Yeh; G Inesi; A Hussain
Journal:  Arch Biochem Biophys       Date:  1999-02-15       Impact factor: 4.013

6.  Specific structural requirements for the inhibitory effect of thapsigargin on the Ca2+ ATPase SERCA.

Authors:  Cheng Xu; Hailun Ma; Giuseppe Inesi; Marwan K Al-Shawi; Chikashi Toyoshima
Journal:  J Biol Chem       Date:  2004-02-17       Impact factor: 5.157

7.  Phosphoryl transfer and calcium ion occlusion in the calcium pump.

Authors:  Thomas Lykke-Møller Sørensen; Jesper Vuust Møller; Poul Nissen
Journal:  Science       Date:  2004-06-11       Impact factor: 47.728

Review 8.  Calcineurin-NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs.

Authors:  Jeffery D Molkentin
Journal:  Cardiovasc Res       Date:  2004-08-15       Impact factor: 10.787

9.  Synthesis and interaction of fluorescent thapsigargin derivatives with the sarcoplasmic reticulum ATPase membrane-bound region.

Authors:  S Hua; H Malak; J R Lakowicz; G Inesi
Journal:  Biochemistry       Date:  1995-04-18       Impact factor: 3.162

10.  Inhibition of the sarcoplasmic reticulum Ca2+ transport ATPase by thapsigargin at subnanomolar concentrations.

Authors:  Y Sagara; G Inesi
Journal:  J Biol Chem       Date:  1991-07-25       Impact factor: 5.157
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  21 in total

1.  Endoplasmic reticulum stress decreases intracellular thyroid hormone activation via an eIF2a-mediated decrease in type 2 deiodinase synthesis.

Authors:  Rafael Arrojo E Drigo; Tatiana L Fonseca; Melany Castillo; Matthias Salathe; Gordana Simovic; Petra Mohácsik; Balazs Gereben; Antonio C Bianco
Journal:  Mol Endocrinol       Date:  2011-11-03

2.  Real-time monitoring of cell elasticity reveals oscillating myosin activity.

Authors:  Hermann Schillers; Mike Wälte; Katarina Urbanova; Hans Oberleithner
Journal:  Biophys J       Date:  2010-12-01       Impact factor: 4.033

3.  Discovery of novel SERCA inhibitors by virtual screening of a large compound library.

Authors:  Christopher Elam; Michael Lape; Joel Deye; Jodie Zultowsky; David T Stanton; Stefan Paula
Journal:  Eur J Med Chem       Date:  2011-02-25       Impact factor: 6.514

4.  Copper-induced calcium release from ER involves the activation of ryanodine-sensitive and IP(3)-sensitive channels in Ulva compressa.

Authors:  Alberto González; Jovanka Trebotich; Eva Vergara; Cristóbal Medina; Bernardo Morales; Alejandra Moenne
Journal:  Plant Signal Behav       Date:  2010-12-01

5.  Binding of anti-GRP78 autoantibodies to cell surface GRP78 increases tissue factor procoagulant activity via the release of calcium from endoplasmic reticulum stores.

Authors:  Ali A Al-Hashimi; Jennifer Caldwell; Mario Gonzalez-Gronow; Salvatore V Pizzo; Danya Aboumrad; Lindsay Pozza; Hiam Al-Bayati; Jeffrey I Weitz; Alan Stafford; Howard Chan; Anil Kapoor; Donald W Jacobsen; Jeffrey G Dickhout; Richard C Austin
Journal:  J Biol Chem       Date:  2010-07-06       Impact factor: 5.157

6.  Effect of cholinergic signaling on neuronal cell bioenergetics.

Authors:  Jianghua Lu; Lezi E; Nairita Roy; Lewis Hutfles; Eva Selfridge; Eric Funk; Jeffrey M Burns; Russell H Swerdlow
Journal:  J Alzheimers Dis       Date:  2013       Impact factor: 4.472

7.  Siphonodictyal B1 from a marine sponge increases intracellular calcium levels comparable to the Ca2+-ATPase (SERCA) inhibitor thapsigargin.

Authors:  Ulf Bickmeyer; Achim Grube; Karl-Walter Klings; Joseph R Pawlik; Matthias Köck
Journal:  Mar Biotechnol (NY)       Date:  2009-07-16       Impact factor: 3.619

8.  Hypoxia-induced cytosolic calcium decrease is mediated primarily by the forward mode of Na(+)/Ca(2+) exchanger in smooth muscle cells of fetal ductus arteriosus.

Authors:  Haifa Hong; Huiwen Chen; Wei Gao; Xiaoman Cai; Yanjuan Sun; Meng Yin; Jinfen Liu
Journal:  Pediatr Cardiol       Date:  2009-06-04       Impact factor: 1.655

9.  Calcium efflux is essential for bacterial survival in the eukaryotic host.

Authors:  Jason W Rosch; Jack Sublett; Geli Gao; Yong-Dong Wang; Elaine I Tuomanen
Journal:  Mol Microbiol       Date:  2008-08-29       Impact factor: 3.501

Review 10.  Intracellular- and extracellular-derived Ca(2+) influence phospholipase A(2)-mediated fatty acid release from brain phospholipids.

Authors:  Angelo O Rosa; Stanley I Rapoport
Journal:  Biochim Biophys Acta       Date:  2009-03-25
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