Literature DB >> 16690340

The impact of genomics on discovering drugs against infectious diseases.

Helena I M Boshoff1, Ujjini H Manjunatha.   

Abstract

Genomics is accelerating the progress in data generation and interpretation in the global analyses of components of cells, including the spectrum of lipids, RNA, metabolites, proteins, mutational phenotypes or DNA methylation sites. Integration of the knowledge generated by these diverse strategies is predicted to have a tremendous impact on approaches to rational drug discovery against infectious diseases.

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Year:  2006        PMID: 16690340     DOI: 10.1016/j.micinf.2005.11.018

Source DB:  PubMed          Journal:  Microbes Infect        ISSN: 1286-4579            Impact factor:   2.700


  1 in total

1.  Co-inhibition of Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase reveals perturbation-specific compensatory mechanisms by transcriptome, proteome, and metabolome analyses.

Authors:  Anna C van Brummelen; Kellen L Olszewski; Daniel Wilinski; Manuel Llinás; Abraham I Louw; Lyn-Marie Birkholtz
Journal:  J Biol Chem       Date:  2008-12-10       Impact factor: 5.157

  1 in total

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