OBJECTIVES: The objectives of this study were (1) to assess the clinical manifestations, treatment, and outcome of Streptococcus suis infection in adult patients in northern Thailand, (2) to evaluate the anti-microbial sensitivity pattern and (3) to determine the predicting factors of high mortality rate. METHODS: A retrospective study was conducted at Chiang Mai University Hospital from May 2000 to December 2002. Anti-microbial susceptibility test was performed by agar disk diffusion and the minimal inhibitory concentration (MIC) by E-test. RESULTS: Forty-one patients (32 men and nine women, mean age 51 years) with S. suis infection were identified. Three patients had a history of exposure to pig or pork and one patient had a history of raw beef consumption. Clinical manifestations included infective endocarditis, meningitis, sepsis, spondylodiscitis, and endophthalmitis in 16, 13, 10, 1, and 1 patients, respectively. The overall mortality rate was 19.5%. On univariate analysis, low serum albumin, high serum total bilirubin, low platelet, and rapid onset of illness were significantly correlated with high mortality rate. All isolates were sensitive to penicillin (mean MIC90=0.027 microg/ml). CONCLUSIONS: S. suis infection is not uncommon in northern Thailand. High suspicion and early detection are important and could lead to the successful treatment.
OBJECTIVES: The objectives of this study were (1) to assess the clinical manifestations, treatment, and outcome of Streptococcus suis infection in adult patients in northern Thailand, (2) to evaluate the anti-microbial sensitivity pattern and (3) to determine the predicting factors of high mortality rate. METHODS: A retrospective study was conducted at Chiang Mai University Hospital from May 2000 to December 2002. Anti-microbial susceptibility test was performed by agar disk diffusion and the minimal inhibitory concentration (MIC) by E-test. RESULTS: Forty-one patients (32 men and nine women, mean age 51 years) with S. suisinfection were identified. Three patients had a history of exposure to pig or pork and one patient had a history of raw beef consumption. Clinical manifestations included infective endocarditis, meningitis, sepsis, spondylodiscitis, and endophthalmitis in 16, 13, 10, 1, and 1 patients, respectively. The overall mortality rate was 19.5%. On univariate analysis, low serum albumin, high serum total bilirubin, low platelet, and rapid onset of illness were significantly correlated with high mortality rate. All isolates were sensitive to penicillin (mean MIC90=0.027 microg/ml). CONCLUSIONS:S. suisinfection is not uncommon in northern Thailand. High suspicion and early detection are important and could lead to the successful treatment.
Authors: Maren Seitz; Andreas Beineke; Alena Singpiel; Jörg Willenborg; Pavel Dutow; Ralph Goethe; Peter Valentin-Weigand; Andreas Klos; Christoph G Baums Journal: Infect Immun Date: 2014-03-31 Impact factor: 3.441
Authors: Jose Antonio Escudero; Alvaro San Millan; Ana Catalan; Adela G de la Campa; Estefania Rivero; Gema Lopez; Lucas Dominguez; Miguel Angel Moreno; Bruno Gonzalez-Zorn Journal: Antimicrob Agents Chemother Date: 2006-11-20 Impact factor: 5.191
Authors: M C Domínguez-Punaro; U Koedel; T Hoegen; C Demel; M Klein; M Gottschalk Journal: Eur J Clin Microbiol Infect Dis Date: 2012-03-01 Impact factor: 3.267
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