Literature DB >> 16690094

Prevalence of Plasmodium falciparum cytochrome b gene mutations in isolates imported from Africa, and implications for atovaquone resistance.

A Berry1, A Senescau, J Lelièvre, F Benoit-Vical, R Fabre, B Marchou, J F Magnaval.   

Abstract

The atovaquone resistance of malaria parasites correlates with mutations in the cytochrome b gene. We sequenced the Plasmodium falciparum cytochrome b gene of 135 African isolates. Our data showed a high mutation rate (8.9%); however, the risk of emergence spreading of atovaquone-resistant P. falciparum strains could be limited.

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Year:  2006        PMID： 16690094     DOI： 10.1016/j.trstmh.2006.02.004

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN： 0035-9203            Impact factor:   2.184


  12 in total

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