| Literature DB >> 16690034 |
Elzbieta Sliwerska1, Fan Meng, Terence P Speed, Edward G Jones, William E Bunney, Huda Akil, Stanley J Watson, Margit Burmeister.
Abstract
Gene expression microarray analysis in postmortem brains is one of the fastest growing fields of psychiatric research. Here we show that common polymorphisms (SNPs) present on probe sets can masquerade as significant "gene expression" differences. After first observing this artifact in the Catechol-O-methyl transferase (COMT) gene, we replicate the finding in two additional genes predicted to show this artifact. Many Affymetrix chips contain thousands of SNPs that are both common and in the central probe region affecting hybridization, and thus have the potential to confound expression analysis.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16690034 DOI： 10.1016/j.biopsych.2006.01.023
Source DB: PubMed Journal: Biol Psychiatry ISSN： 0006-3223 Impact factor: 13.382