| Literature DB >> 16688533 |
Emmanuelle Abgueguen1, Bertrand Toutain, Hélène Bédrine, Céline Chicault, Magali Orhant, Marc Aubry, Annabelle Monnier, Stéphanie Mottier, Hélène Jouan, Seiamak Bahram, Jean Mosser, Patricia Fergelot.
Abstract
Iron absorption, distribution, use, and storage are thought to be tightly regulated since altered iron stores may lead to cellular damage and disease. HFE, the hereditary hemochromatosis gene product, is expressed in the crypts of the duodenum, but the molecular mechanism by which it contributes to the inhibition of iron absorption is still unknown. In this study we aimed to identify transcriptional profiles in the duodenal epithelium of Hfe(-/-) mice. We used dedicated microarrays to compare gene expression among the duodenum of Hfe(-/-) mice, induced iron overload mice, and control mice. We found 151 differentially expressed genes and unknown sequences between Hfe(-/-) mice and normal littermates. Gene profiling revealed a gene subset more specific for Hfe inactivation. The functional annotation of upregulated genes highlighted that mucus production and cell maintenance may account for the influence of Hfe on epithelium integrity and luminal iron uptake.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16688533 DOI： 10.1007/s00335-005-0122-z
Source DB: PubMed Journal: Mamm Genome ISSN： 0938-8990 Impact factor: 2.957