OBJECTIVES: Cadmium (Cd) and lead (Pb) have been demonstrated to exert endocrine disrupting activities. Their possible role in endometriosis, an oestrogen-dependent disease, is unknown. METHODS: We compared cadmium urinary excretion (CdU) and blood concentration of cadmium (CdB) and lead (PbB) in 119 patients with peritoneal endometriosis and/or deep endometriotic (adenomyotic) nodules of the rectovaginal septum and 25 controls. RESULTS: The mean levels of cadmium in urine and blood did not differ among the groups. Women suffering from endometriotic diseases showed lower levels of PbB than controls. CONCLUSIONS: These data do not support a role for cadmium in the onset or the growth of endometriotic diseases but suggest a possible relationship with lead.
OBJECTIVES:Cadmium (Cd) and lead (Pb) have been demonstrated to exert endocrine disrupting activities. Their possible role in endometriosis, an oestrogen-dependent disease, is unknown. METHODS: We compared cadmium urinary excretion (CdU) and blood concentration of cadmium (CdB) and lead (PbB) in 119 patients with peritoneal endometriosis and/or deep endometriotic (adenomyotic) nodules of the rectovaginal septum and 25 controls. RESULTS: The mean levels of cadmium in urine and blood did not differ among the groups. Women suffering from endometriotic diseases showed lower levels of PbB than controls. CONCLUSIONS: These data do not support a role for cadmium in the onset or the growth of endometriotic diseases but suggest a possible relationship with lead.
Authors: Anna Z Pollack; Germaine M Buck Louis; Zhen Chen; C Matthew Peterson; Rajeshwari Sundaram; Mary S Croughan; Liping Sun; Mary L Hediger; Joseph B Stanford; Michael W Varner; Christopher D Palmer; Amy J Steuerwald; Patrick J Parsons Journal: Reprod Toxicol Date: 2013-07-23 Impact factor: 3.143
Authors: Lidia Caporossi; Silvia Capanna; Paola Viganò; Alessandra Alteri; Bruno Papaleo Journal: Int J Environ Res Public Health Date: 2021-01-11 Impact factor: 3.390