Literature DB >> 16686876

Use of antibiotics in elderly patients with exacerbated COPD: the OLD-chronic obstructive pulmonary disease study.

Raffaele Antonelli Incalzi1, Andrea Corsonello, Claudio Pedone, Giulio Masotti, Franco Rengo, Vittorio Grassi, Vincenzo Bellia.   

Abstract

OBJECTIVES: To verify how frequently geriatric patients hospitalized for exacerbated chronic obstructive pulmonary disorder (COPD) had not been given antibiotics at home and to identify the relationship between the patient's condition and the prescribing practice.
DESIGN: Observational study.
SETTING: General medicine acute care wards. PARTICIPANTS: Four hundred fifty-nine elderly patients admitted to the hospital because of exacerbated COPD. MEASUREMENTS: Indices of severity of COPD exacerbation, such as age, St. George Respiratory Questionnaire (SGRQ) score, number of exacerbations in the previous year, and Cumulative Illness Rating Scale score were considered in the analyses.
RESULTS: Ninety (19.6%) patients had an antibiotic prescribed before admission. The prescription was not associated with older age and was weakly associated with greater comorbidity. Having more than four exacerbations (odds ratio (OR)=2.16, 95% confidence interval (CI)=1.27-3.66) and a SGRQ symptoms subscore greater than 70 (OR=1.61, 95% CI=1.0-2.68) were independent correlates of the use of antibiotics before admission, although 67% of patients reporting more than four exacerbations in the previous year and 73.1% of patients with a SGRQ symptoms subscore greater than 70 had not been given any antibiotic prescription at home.
CONCLUSION: The majority of older patients hospitalized for exacerbated COPD had not been given antibiotics at home, although they had at least one index of exacerbation severity.

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Year:  2006        PMID: 16686876     DOI: 10.1111/j.1532-5415.2006.00680.x

Source DB:  PubMed          Journal:  J Am Geriatr Soc        ISSN: 0002-8614            Impact factor:   5.562


  3 in total

1.  From Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines to current clinical practice : an overview of the pharmacological therapy of stable chronic obstructive pulmonary disorder.

Authors:  Raffaele Antonelli Incalzi; Andrea Corsonello; Claudio Pedone; Giulio Masotti; Vincenzo Bellia; Vittorio Grassi; Franco Rengo
Journal:  Drugs Aging       Date:  2006       Impact factor: 3.923

2.  Previous outpatient antibiotic use in patients admitted to hospital for COPD exacerbations: room for improvement.

Authors:  M Miravitlles; J J Soler-Cataluña; F Baranda; P Cordero; J-V Greses; C de la Roza
Journal:  Infection       Date:  2012-08-21       Impact factor: 3.553

3.  Determinants of chronic obstructive pulmonary disease severity in the late-elderly differ from those in younger patients.

Authors:  Mizuha Haraguchi; Hidetoshi Nakamura; Mamoru Sasaki; Masaki Miyazaki; Shotaro Chubachi; Saeko Takahashi; Koichiro Asano; Paul W Jones; Tomoko Betsuyaku
Journal:  BMC Res Notes       Date:  2016-01-04
  3 in total

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